GPCRs modulate a plethora of physiological processes and mediate the effects of one‐third
of FDA‐approved drugs. Depending on which ligand activates a receptor, it can engage …

G protein-gated inwardly rectifying K+ (GIRK/Kir3) channels exert a critical inhibitory
influence on neurons. Neuronal GIRK channels mediate the G protein-dependent …

G protein-coupled receptors are important drug targets that engage and activate signaling
transducers in multiple cellular compartments. Delineating therapeutic signaling from …

Intracellular G protein-coupled receptors (GPCRs) can be activated by permeant ligands,
which contributes to agonist selectivity. Opioid receptors (ORs) provide a notable example …

G protein–coupled receptors (GPCRs) regulate cellular signaling processes by coupling to
diverse combinations of heterotrimeric G proteins composed of Gα, Gβ, and Gγ subunits …

G protein-coupled receptors (GPCRs) convert extracellular stimuli into intracellular signaling
by coupling to heterotrimeric G proteins of four classes: G i/o, G q, G s, and G 12/13 …

A long-held tenet in inositol-lipid signaling is that cleavage of membrane phosphoinositides
by phospholipase Cβ (PLCβ) isozymes to increase cytosolic Ca2+ in living cells is exclusive …

G protein-coupled receptors (GPCRs) are the largest family of druggable proteins encoded
in the human genome, but progress in understanding and targeting them is hindered by the …

G protein-coupled receptors (GPCRs) are ligand-activated cell membrane proteins and
represent the most important class of drug targets. GPCRs adopt several active …

G-protein-coupled receptors (GPCRs) and G-proteins have a range of roles in many
physiological and pathological processes and are among the most studied signaling …