Peroxisome proliferator-activated receptor-α (PPARα), PPARδ and PPARγ are transcription
factors that regulate gene expression following ligand activation. PPARα increases cellular …

Pulmonary arterial hypertension (PAH) is a devastating disease that involves pulmonary
vasoconstriction, small vessel obliteration, large vessel thickening and obstruction, and …

Alterations in DNA damage response (DDR) pathways are hallmarks of cancer. Incorrect
repair of DNA lesions often leads to genomic instability. Ataxia telangiectasia mutated …

Pulmonary arterial hypertension (PAH) is a progressive disease in which pulmonary arterial
(PA) endothelial cell (EC) dysfunction is associated with unrepaired DNA damage. BMPR2 …

Rationale: In pulmonary arterial hypertension (PAH), endothelial dysfunction and obliterative
vascular disease are associated with DNA damage and impaired signaling of BMPR2 (bone …

The dynamic regulation of endothelial pathophenotypes in pulmonary hypertension (PH)
remains undefined. Cellular senescence is linked to PH with intracardiac shunts; however …

Pulmonary vascular remodeling is the critical structural alteration and pathological feature in
pulmonary hypertension (PH) and involves changes in the intima, media and adventitia …

Objective: Mutations in BMPR2 (bone morphogenetic protein receptor 2) are associated with
familial and sporadic pulmonary arterial hypertension (PAH). The functional and molecular …

Background Colitis-associated colorectal cancer (CAC) is a severe complication of
inflammatory bowel disease (IBD), resulting from long-term inflammation in the intestines …

Understanding the molecular determinants that underpin the clinical heterogeneity of non-
muscle-invasive bladder cancer (NMIBC) is essential for prognostication and therapy …