The roles of neurotrophins in traumatic brain injury
Neurotrophins are a collection of structurally and functionally related proteins. They play
important roles in many aspects of neural development, survival, and plasticity. Traumatic …
important roles in many aspects of neural development, survival, and plasticity. Traumatic …
Brain repair mechanisms after cell therapy for stroke
Cell-based therapies hold great promise for brain repair after stroke. While accumulating
evidence confirms the preclinical and clinical benefits of cell therapies, the underlying …
evidence confirms the preclinical and clinical benefits of cell therapies, the underlying …
Transplantation of Roxadustat‐preconditioned bone marrow stromal cells improves neurological function recovery through enhancing grafted cell survival in ischemic …
J Chen, X Lin, C Yao, LA Bingwa… - CNS Neuroscience …, 2022 - Wiley Online Library
Aims The therapeutic effect of bone marrow stromal cell (BMSC) transplantation for ischemic
stroke is limited by its low survival rate. The purpose of this study was to evaluate whether …
stroke is limited by its low survival rate. The purpose of this study was to evaluate whether …
Systematic review and meta-analysis of preclinical studies testing mesenchymal stromal cells for traumatic brain injury
F Pischiutta, E Caruso, A Lugo, H Cavaleiro… - NPJ Regenerative …, 2021 - nature.com
Mesenchymal stromal cells (MSCs) are widely used in preclinical models of traumatic brain
injury (TBI). Results are promising in terms of neurological improvement but are hampered …
injury (TBI). Results are promising in terms of neurological improvement but are hampered …
LDC7559 exerts neuroprotective effects by inhibiting GSDMD-dependent pyroptosis of microglia in mice with traumatic brain injury
E Yu, E Zhang, X Lv, L Yan, Z Lin… - Journal of …, 2023 - liebertpub.com
Pyroptosis is considered one of a critical factor in the recovery of neurological function
following traumatic brain injury. Brain injury activates a molecular signaling cascade …
following traumatic brain injury. Brain injury activates a molecular signaling cascade …
Preconditioning with secretome of neural crest-derived stem cells enhanced neurotrophic expression in mesenchymal stem cells
S Karimi-Haghighi, S Chavoshinezhad, A Safari… - Neuroscience …, 2022 - Elsevier
During the last 20 years, stem cell therapy has been considered as an effective approach for
regenerative medicine. Due to poor ability of stem cells to survive following transplantation, it …
regenerative medicine. Due to poor ability of stem cells to survive following transplantation, it …
Potential of mesenchymal stem cells alone, or in combination, to treat traumatic brain injury
Traumatic brain injury (TBI) causes death and disability in the United States and around the
world. The traumatic insult causes the mechanical injury of the brain and primary cellular …
world. The traumatic insult causes the mechanical injury of the brain and primary cellular …
Antagonism of Protease-Activated Receptor 4 Protects Against Traumatic Brain Injury by Suppressing Neuroinflammation via Inhibition of Tab2/NF-κB Signaling
J Luo, X Wu, H Liu, W Cui, W Guo, K Guo, H Guo… - Neuroscience …, 2021 - Springer
Traumatic brain injury (TBI) triggers the activation of the endogenous coagulation
mechanism, and a large amount of thrombin is released to curb uncontrollable bleeding …
mechanism, and a large amount of thrombin is released to curb uncontrollable bleeding …
The pros and cons of motor, memory, and emotion-related behavioral tests in the mouse traumatic brain injury model
R Zhang, J Wang, L Huang, TJ Wang… - Neurological …, 2022 - Taylor & Francis
Traumatic brain injury (TBI) is a medical emergency with high morbidity and mortality. Motor,
memory, and emotion-related deficits are common symptoms following TBI, yet treatment is …
memory, and emotion-related deficits are common symptoms following TBI, yet treatment is …
Human Umbilical Cord–Derived Mesenchymal Stem Cell Therapy Effectively Protected the Brain Architecture and Neurological Function in Rat After Acute Traumatic …
KH Chen, PL Shao, YC Li, JY Chiang… - Cell …, 2020 - journals.sagepub.com
Intracranial hemorrhage from stroke and head trauma elicits a cascade of inflammatory and
immune reactions detrimental to neurological integrity and function at cellular and molecular …
immune reactions detrimental to neurological integrity and function at cellular and molecular …