Abstract The APOBEC3 (A3) proteins are host antiviral cellular proteins that hypermutate the
viral genome of diverse viral families. In retroviruses, this process requires A3 packaging …

Human APOBEC3G (A3G) is a virus restriction factor that inhibits HIV-1 replication and
triggers lethal hypermutation on viral reverse transcripts. HIV-1 viral infectivity factor (Vif) …

Apo lipoprotein B mRNA e diting c atalytic polypeptide-like (APOBEC) proteins belong to a
family of deaminase proteins that can catalyze the deamination of cytosine to uracil on …

Highlights•Specificity of APOBEC3 proteins is determined by 4 active site loops•ssDNA
adopts different conformations dependent on the APOBEC3 enzyme•Regions remote from …

An essential step in restricting HIV infectivity by the antiviral factor APOBEC3G is its
incorporation into progeny virions via binding to HIV RNA. However, the mechanism of …

Host restriction factor APOBEC3G (A3G) efficiently restricts Vif-deficient HIV-1 by being
packaged with progeny virions and causing the G to A mutation during HIV-1 viral DNA …

APOBEC3 enzymes are polynucleotide deaminases, converting cytosine to uracil on single-
stranded DNA (ssDNA) and RNA as part of the innate immune response against viruses and …

APOBEC3 family members are cytidine deaminases catalyzing conversion of cytidine to
uracil. Many studies have established a link between APOBEC3 expression and cancer …

The APOBEC3 (A3) genes encode cytidine deaminase proteins with potent antiviral and anti-
retroelement activity. This locus is characterized by duplication, recombination, and deletion …

Abstract APOBEC3G (A3G) belongs to the AID/APOBEC cytidine deaminase family and is
essential for antiviral immunity. It contains two zinc-coordinated cytidine-deaminase (CD) …