Neurodevelopmental disorders (NDDs), including intellectual disability (ID) and autism
spectrum disorders (ASD), are a large group of disorders in which early insults during brain …

An increasing number of epilepsies are being attributed to variants in genes with epigenetic
functions. The products of these genes include factors that regulate the structure and …

The prevalence of autism spectrum disorder (ASD)—a type of neurodevelopmental disorder—
is increasing and is around 2% in North America, Asia, and Europe. Besides the known …

Background Tissue clearing is currently revolutionizing neuroanatomy by enabling organ-
level imaging with cellular resolution. However, currently available tools for data analysis …

Autism is a complex condition with many traits, including differences in auditory sensitivity.
Studies in human autism are plagued by the difficulty of controlling for aetiology, whereas …

Genetic evidence indicates disrupted epigenetic regulation as a major risk factor for
psychiatric disorders, but the molecular mechanisms that drive this association remain to be …

The etiology of neurodevelopmental disorders (NDDs) remains a challenge for researchers.
Human brain development is tightly regulated and sensitive to cellular alterations caused by …

Pharmacological options for neurodevelopmental disorders are limited to symptom
suppressing agents that do not target underlying pathophysiological mechanisms. Studies …

Kleefstra syndrome in humans is characterized by a general delay in development,
intellectual disability and autistic features. The mouse model of this disease (Ehmt1±) …

Epilepsy and epileptiform patterns of cortical activity are highly prevalent in autism spectrum
disorders (ASDs), but the neural substrates and pathophysiological mechanisms underlying …