Quantification methods for viruses and virus-like particles applied in biopharmaceutical production processes
Introduction Effective cell-based production processes of virus particles are the foundation
for the global availability of classical vaccines, gene therapeutic vectors, and viral oncolytic …
for the global availability of classical vaccines, gene therapeutic vectors, and viral oncolytic …
Airborne fine particles drive H1N1 viruses deep into the lower respiratory tract and distant organs
Z Dong, J Ma, J Qiu, Q Ren, Q Shan, X Duan, G Li… - Science …, 2023 - science.org
Mounting data suggest that environmental pollution due to airborne fine particles (AFPs)
increases the occurrence and severity of respiratory virus infection in humans. However, it is …
increases the occurrence and severity of respiratory virus infection in humans. However, it is …
Secondary streptococcal infection following influenza
N Okahashi, T Sumitomo, M Nakata… - Microbiology and …, 2022 - Wiley Online Library
Secondary bacterial infection following influenza type A virus (IAV) infection is a major cause
of morbidity and mortality during influenza epidemics. Streptococcus pneumoniae has been …
of morbidity and mortality during influenza epidemics. Streptococcus pneumoniae has been …
XAF1 protects host against emerging RNA viruses by stabilizing IRF1-dependent antiviral immunity
Y Han, X Bai, S Liu, J Zhu, F Zhang, L Xie, G Liu… - Journal of …, 2022 - Am Soc Microbiol
ABSTRACT XIAP-associated factor 1 (XAF1) is an interferon (IFN)-stimulated gene (ISG) that
enhances IFN-induced apoptosis. However, it is unexplored whether XAF1 is essential for …
enhances IFN-induced apoptosis. However, it is unexplored whether XAF1 is essential for …
An optimized high-throughput immuno-plaque assay for SARS-CoV-2
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been identified as the
causative agent of coronavirus disease 2019 and is capable of human-to-human …
causative agent of coronavirus disease 2019 and is capable of human-to-human …
Adenosine Triphosphate Release From Influenza-Infected Lungs Enhances Neutrophil Activation and Promotes Disease Progression
C Ledderose, EA Valsami, M Elevado… - The Journal of …, 2024 - academic.oup.com
Background Adenosine triphosphate (ATP) enhances neutrophil responses, but little is
known about the role of ATP in influenza infections. Methods We used a mouse influenza …
known about the role of ATP in influenza infections. Methods We used a mouse influenza …
Synthesis of novel aminothiazole derivatives as promising antiviral, antioxidant and antibacterial candidates
R Minickaitė, B Grybaitė, R Vaickelionienė… - International Journal of …, 2022 - mdpi.com
It is well-known that thiazole derivatives are usually found in lead structures, which
demonstrate a wide range of pharmacological effects. The aim of this research was to …
demonstrate a wide range of pharmacological effects. The aim of this research was to …
TRIM25 inhibits influenza A virus infection, destabilizes viral mRNA, but is redundant for activating the RIG-I pathway
NR Choudhury, I Trus, G Heikel, M Wolczyk… - Nucleic Acids …, 2022 - academic.oup.com
The E3 ubiquitin ligase TRIM25 is a key factor in the innate immune response to RNA
viruses. TRIM25 has been shown to play a role in the retinoic-acid-inducible gene-1 (RIG-I) …
viruses. TRIM25 has been shown to play a role in the retinoic-acid-inducible gene-1 (RIG-I) …
Oral immunization with rVSV bivalent vaccine elicits protective immune responses, including ADCC, against both SARS-CoV-2 and Influenza A viruses
MJ Ouyang, Z Ao, TA Olukitibi, P Lawrynuik, C Shieh… - Vaccines, 2023 - mdpi.com
COVID-19 and influenza both cause enormous disease burdens, and vaccines are the
primary measures for their control. Since these viral diseases are transmitted through the …
primary measures for their control. Since these viral diseases are transmitted through the …
Immunogenicity and Cross-Protective Efficacy Induced by an Inactivated Recombinant Avian Influenza A/H5N1 (Clade 2.3. 4.4 b) Vaccine against Co-Circulating …
SH Mahmoud, AA Khalil, NM Abo Shama, MF El Sayed… - Vaccines, 2023 - mdpi.com
Controlling avian influenza viruses (AIVs) is mainly based on culling of the infected bird
flocks or via the implementation of inactivated vaccines in countries where AIVs are …
flocks or via the implementation of inactivated vaccines in countries where AIVs are …