Fine-tuning cellular physiology in response to intracellular and environmental cues requires
precise temporal and spatial control of gene expression. High-resolution imaging …

The spatial regulation of protein translation is an efficient way to create functional and
structural asymmetries in cells. Recent research has furthered our understanding of how …

Pioneering electron microscopy studies defined two primary populations of ribosomes in
eukaryotic cells: one freely dispersed through the cytoplasm and the other bound to the …

Ribosome-associated factors must properly decode the limited information available in
nascent polypeptides to direct them to their correct cellular fate. It is unclear how the low …

Protein transport via the Sec translocon represents an evolutionary conserved mechanism
for delivering cytosolically-synthesized proteins to extra-cytosolic compartments. The Sec …

In a previous analysis of 2300 mRNAs via whole-mount fluorescent in situ hybridization in
cellularizing Drosophila embryos, we found that 70% of the transcripts exhibited some form …

Local synthesis of proteins near their activity site has been demonstrated in many biological
systems, and has diverse contributions to cellular functions. Studies in recent years have …

Saccharomyces cerevisiae can serve as a key production platform for biofuels,
nutraceuticals, industrial compounds, and therapeutic proteins. Over the recent years …

The binding of sequence-specific RNA-interacting proteins, such as the bacteriophage MS2
or PP7 coat proteins, to their corresponding target sequences has been extremely useful …

Genome duplication in eukaryotes created paralog pairs of ribosomal proteins (RPs) that
show high sequence similarity/identity. However, individual paralogs can confer vastly …