Platelets serve as “first responders” during normal wounding and homeostasis. Arising from
bone marrow stem cell lineage megakaryocytes, anucleate platelets can influence …

Atherosclerosis is one of the key problems of modern medicine, which is due to the high
prevalence of atherosclerotic cardiovascular diseases and their significant share in the …

Acute respiratory distress syndrome (ARDS) is a serious complication of severe systemic or
local pulmonary inflammation, such as caused by severe acute respiratory syndrome …

Pulmonary arterial hypertension (PAH) is a debilitating and progressive disease that
predominantly develops in women. Over the past 15 years, cumulating evidence has …

We have established considerable expertise in studying the role of platelets in cancer
biology. From this expertise, we were keen to recognize the numerous venous-, arterial …

The European guidelines, which focus on clinical aspects of pulmonary hypertension (PH),
provide only minimal information about the pathophysiological concepts of PH. Here, we …

Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid via cytochrome P450
(CYP)/epoxygenase and are hydrolyzed by soluble epoxide hydrolase (sEH). Circulating …

Patients with primary aldosteronism (PA) have increased risk of target-organ damage,
among which vascular calcification is an important indicator of cardiovascular mortality. 14 …

The term “antibiotics” is a broadly used misnomer to designate antibacterial drugs. In a
recent article, we have proposed to replace, eg, the term “antibiotics” by “antibacterial …

Epoxyeicosatrienoic acids (EETs) are epoxy fatty acids that have biological actions that are
essential for maintaining water and electrolyte homeostasis. An inability to increase EETs in …