MicroRNAs: from mechanism to organism
PJ Dexheimer, L Cochella - Frontiers in cell and developmental …, 2020 - frontiersin.org
MicroRNAs (miRNAs) are short, regulatory RNAs that act as post-transcriptional repressors
of gene expression in diverse biological contexts. The emergence of small RNA-mediated …
of gene expression in diverse biological contexts. The emergence of small RNA-mediated …
Evolution of microRNA diversity and regulation in animals
E Berezikov - Nature Reviews Genetics, 2011 - nature.com
In the past decade, microRNAs (miRNAs) have been uncovered as key regulators of gene
expression at the post-transcriptional level. The ancient origin of miRNAs, their dramatic …
expression at the post-transcriptional level. The ancient origin of miRNAs, their dramatic …
miREvo: an integrative microRNA evolutionary analysis platform for next-generation sequencing experiments
Background MicroRNAs (miRNAs) are small (~ 19-24nt) non-coding RNAs that play
important roles in various biological processes. To date, the next-generation sequencing …
important roles in various biological processes. To date, the next-generation sequencing …
[HTML][HTML] Evolution of genes and genomes on the Drosophila phylogeny
Comparative analysis of multiple genomes in a phylogenetic framework dramatically
improves the precision and sensitivity of evolutionary inference, producing more robust …
improves the precision and sensitivity of evolutionary inference, producing more robust …
Origins and evolution of eukaryotic RNA interference
SA Shabalina, EV Koonin - Trends in ecology & evolution, 2008 - cell.com
Small interfering RNAs (siRNAs) and genome-encoded microRNAs (miRNAs) silence genes
via complementary interactions with mRNAs. With thousands of miRNA genes identified and …
via complementary interactions with mRNAs. With thousands of miRNA genes identified and …
New gene evolution: little did we know
Genes are perpetually added to and deleted from genomes during evolution. Thus, it is
important to understand how new genes are formed and how they evolve to be critical …
important to understand how new genes are formed and how they evolve to be critical …
Impact of microRNA regulation on variation in human gene expression
MicroRNAs (miRNAs) are endogenously expressed small RNAs that regulate expression of
mRNAs at the post-transcriptional level. The consequence of miRNA regulation is …
mRNAs at the post-transcriptional level. The consequence of miRNA regulation is …
Genomic reaction norms: using integrative biology to understand molecular mechanisms of phenotypic plasticity
N Aubin‐Horth, SCP Renn - Molecular ecology, 2009 - Wiley Online Library
Phenotypic plasticity is the development of different phenotypes from a single genotype,
depending on the environment. Such plasticity is a pervasive feature of life, is observed for …
depending on the environment. Such plasticity is a pervasive feature of life, is observed for …
microRNAs in the same clusters evolve to coordinately regulate functionally related genes
MicroRNAs (miRNAs) are endogenously expressed small noncoding RNAs. The genomic
locations of animal miRNAs are significantly clustered in discrete loci. We found duplication …
locations of animal miRNAs are significantly clustered in discrete loci. We found duplication …