When type III interferon (IFN-λ; also known as interleukin-28 [IL-28] and IL-29) was
discovered in 2003, its antiviral function was expected to be analogous to that of type I IFNs …

Interferons (IFNs) are very powerful cytokines, which play a key role in combatting pathogen
infections by controlling inflammation and immune response by directly inducing anti …

Type III interferons (IFNs) or IFN-λs regulate a similar set of genes as type I IFNs, but
whereas type I IFNs act globally, IFN-λs primarily target mucosal epithelial cells and protect …

Type I and III interferons (IFNs) activate similar downstream signaling cascades, but unlike
type I IFNs, type III IFNs (IFNλ) do not elicit strong inflammatory responses in vivo. Here, we …

Advancing our understanding of mechanisms of immune regulation in allergy, asthma,
autoimmune diseases, tumor development, organ transplantation, and chronic infections …

The epithelium is the main entry point for many viruses, but the processes that protect barrier
surfaces against viral infections are incompletely understood. Here we identified interleukin …

Cytokines and chemokines are secreted proteins involved in numerous aspects of cell
growth, differentiation, and activation. A prominent feature of these molecules is their effect …

The interferons (IFNs) are glycoproteins with strong antiviral activities that represent one of
the first lines of host defense against invading pathogens. These proteins are classified into …

Interferons (IFN) exert antiviral, immunomodulatory and cytostatic activities. IFN-α/β (type I
IFN) and IFN-λ (type III IFN) bind distinct receptors, but regulate similar sets of genes and …

Cytokines play a very important role in nearly all aspects of inflammation and immunity. The
term'interleukin'(IL) has been used to describe a group of cytokines with complex …