The progressive increase in lifespan over the past century carries with it some adversity
related to the accompanying burden of debilitating diseases prevalent in the older …

As the population ages due to demographic trends and gains in life expectancy, the
incidence and prevalence of dementia increases, and the need to understand the etiology …

BACKGROUND: Studies suggest that inflammation is involved in the neurodegenerative
cascade leading to Alzheimer's disease (AD) pathology and symptoms. This study sought to …

None of the proposed mechanisms of Alzheimer's disease (AD) fully explains the distribution
patterns of the neuropathological changes at the cellular and regional levels, and their …

Carbazole skeleton is the key structural motif of many biologically active compounds
including synthetic and natural products. Over the past several years, a large number of …

Background: Despite the US Food and Drug Administration (FDA) warning regarding
cognitive impairment, the relationship between statins and cognition remains unknown …

Alzheimer's disease is a neurodegenerative disorder in which the pathological accumulation
of amyloid-β and tau begins years before symptom onset. Emerging evidence suggests that …

The brain noradrenergic system supplies the neurotransmitter norepinephrine throughout
the brain via widespread efferent projections, and plays a pivotal role in modulating …

The mechanisms underlying ryanodine receptor (RyR) dysfunction associated with
Alzheimer disease (AD) are still not well understood. Here, we show that neuronal RyR2 …

Objectives Progression of Alzheimer dementia (AD) is highly variable. Most estimates derive
from convenience samples from dementia clinics or research centers where there is …