Vaccine adjuvants: Mechanisms and platforms

T Zhao, Y Cai, Y Jiang, X He, Y Wei, Y Yu… - Signal transduction and …, 2023 - nature.com
Adjuvants are indispensable components of vaccines. Despite being widely used in
vaccines, their action mechanisms are not yet clear. With a greater understanding of the …

[HTML][HTML] Mutations of SARS-CoV-2 spike protein: Implications on immune evasion and vaccine-induced immunity

HM Mengist, AJK Kombe, D Mekonnen, A Abebaw… - Seminars in …, 2021 - Elsevier
Responsible for more than 4.9 million deaths so far, COVID-19, caused by SARS-CoV-2, is
instigating devastating effects on the global health care system whose impacts could be …

Structural and non-structural proteins in SARS-CoV-2: potential aspects to COVID-19 treatment or prevention of progression of related diseases

S Kakavandi, I Zare, M VaezJalali, M Dadashi… - Cell Communication and …, 2023 - Springer
Abstract Coronavirus disease 2019 (COVID-19) is caused by a new member of the
Coronaviridae family known as severe acute respiratory syndrome coronavirus 2 (SARS …

Comparative immunogenicity of the recombinant receptor-binding domain of protein S SARS-CoV-2 obtained in prokaryotic and mammalian expression systems

IA Merkuleva, DN Shcherbakov, MB Borgoyakova… - Vaccines, 2022 - mdpi.com
The receptor-binding domain (RBD) of the protein S SARS-CoV-2 is considered to be one of
the appealing targets for developing a vaccine against COVID-19. The choice of an …

Saponins: research progress and their potential role in the Post-COVID-19 pandemic Era

D Mieres-Castro, F Mora-Poblete - Pharmaceutics, 2023 - mdpi.com
In the post-COVID-19 pandemic era, the new global situation and the limited therapeutic
management of the disease make it necessary to take urgent measures in more effective …

Novel receptor, mutation, vaccine, and establishment of coping mode for SARS-CoV-2: current status and future

Z Zeng, X Geng, X Wen, Y Chen, Y Zhu… - Frontiers in …, 2023 - frontiersin.org
Since the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and
its resultant pneumonia in December 2019, the cumulative number of infected people …

[HTML][HTML] Design, evaluation, and immune simulation of potentially universal multi-epitope mpox vaccine candidate: focus on DNA vaccine

N Rcheulishvili, J Mao, D Papukashvili… - Frontiers in …, 2023 - frontiersin.org
Monkeypox (mpox) is a zoonotic infectious disease caused by the mpox virus. Mpox
symptoms are similar to smallpox with less severity and lower mortality. As yet mpox virus is …

Bioinformatics designing and molecular modelling of a universal mRNA vaccine for SARS-CoV-2 infection

EK Oladipo, MO Adeniyi, MT Ogunlowo, BA Irewolede… - Vaccines, 2022 - mdpi.com
At this present stage of COVID-19 re-emergence, designing an effective candidate vaccine
for different variants of SARS-CoV-2 is a study worthy of consideration. This research used …

A-910823, a squalene-based emulsion adjuvant, induces T follicular helper cells and humoral immune responses via α-tocopherol component

Y Yoshioka, K Kobiyama, T Hayashi, M Onishi… - Frontiers in …, 2023 - frontiersin.org
Background Adjuvants are chemical or biological materials that enhance the efficacy of
vaccines. A-910823 is a squalene-based emulsion adjuvant used for S-268019-b, a novel …

Screening of efficient adjuvants for the RBD-based subunit vaccine of SARS-CoV-2

J Shi, Y Zhao, M Peng, S Zhu, Y Wu, R Ji, C Shen - Vaccines, 2023 - mdpi.com
The variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are more
transmissible, with a reduced sensitivity to vaccines targeting the original virus strain …