NF-κB-iNOS-COX2-TNF α inflammatory signaling pathway plays an important role in methotrexate induced small intestinal injury in rats
K Natarajan, P Abraham, R Kota, B Isaac - Food and chemical toxicology, 2018 - Elsevier
Although methotrexate is widely used in clinics as an anticancer agent, it's utility is limited by
its gastrointestinal toxicity, the mechanism of which is unclear. The role of NFκB …
its gastrointestinal toxicity, the mechanism of which is unclear. The role of NFκB …
Evaluation of anticonvulsant activity of dual COX-2/5-LOX inhibitor darbufelon and its novel analogues
M Mishchenko, S Shtrygol', A Lozynskyi… - Scientia …, 2021 - mdpi.com
Neuroinflammation is an integral part of epilepsy pathogenesis and other convulsive
conditions, and non-steroidal anti-inflammatory drugs (NSAIDs) present a potent tool for the …
conditions, and non-steroidal anti-inflammatory drugs (NSAIDs) present a potent tool for the …
HNet-DNN: inferring new drug–disease associations with deep neural network based on heterogeneous network features
Drug research and development is a time-consuming and high-cost task, pressing an urgent
demand to identify novel indications of approved drugs, referred to as drug repositioning …
demand to identify novel indications of approved drugs, referred to as drug repositioning …
[PDF][PDF] Antimicrobial and cytotoxic activities of thiazolo [4, 5-b] pyridine derivatives
Aim. The screening of antimicrobial and cytotoxic activities of thiazolo [4, 5-b] pyridine
derivatives was accomplished. Methods. The antibacterial and antifungal activities of …
derivatives was accomplished. Methods. The antibacterial and antifungal activities of …
[PDF][PDF] Synthesis and evaluation of biological activity of rhodanine-pyrazoline hybrid molecules with 2-(2, 6-dichlorophenylamino)-phenylacetamide fragment
Aim. Synthesis of new rhodanine-pyrazoline hybrid molecules with a diclofenac fragment in
position 3 using the reactions of heterocyclization and aminolysis with potential antitumor …
position 3 using the reactions of heterocyclization and aminolysis with potential antitumor …
Potential role of carvedilol in intestinal toxicity through NF-κB/iNOS/COX-2/TNF-α inflammatory signaling pathway in rats
AM Abdel-Aziz, YF Ibrahim, RF Ahmed… - …, 2022 - Taylor & Francis
Background The increased use of indomethacin (IND) is associated with gastrointestinal
injury. This research aims to investigate the effects of a beta-blocker, carvedilol (CAR) on a …
injury. This research aims to investigate the effects of a beta-blocker, carvedilol (CAR) on a …
[PDF][PDF] New polyfunctionalized 2-hydrazinoanthraquinone derivatives as potential antimicrobial agents
Aim. Synthesis and study of new polyfunctionalized 2-hydrazinoanthraquinone derivatives
as potential antimicrobial agents. Methods. Organic synthesis, NMR and LC-MS …
as potential antimicrobial agents. Methods. Organic synthesis, NMR and LC-MS …
[PDF][PDF] Synthesis and evaluation of biological activity of 1-[2-amino-4-methylthiazol-5-yl]-3-arylpropenones
Aim. To accomplish the synthesis and screening of anticancer and antimicrobial activities of
1-[2-amino-4-methylthiazol-5-yl]-3-arylpropenones 2-10. Methods. The in vitro anticancer …
1-[2-amino-4-methylthiazol-5-yl]-3-arylpropenones 2-10. Methods. The in vitro anticancer …
[PDF][PDF] Influence of the 4-thiazolidinone derivative Les-6490 on the inflammatory process in rats compared to nimesulide
TM Rumynska, IM Yushyn, SM Holota… - Biopolymers and …, 2024 - researchgate.net
Nonsteroidal anti-inflammatory drugs (NSAIDs), used in the treatment of numerous
diseases, can cause a number of side effects, the main of which is an ulcerogenic effect on …
diseases, can cause a number of side effects, the main of which is an ulcerogenic effect on …
Anti-inflammatory hydrogen sulfide-releasing agents with reduced gastro-and enterotoxicity on the stress model in rats.
BACKGROUND: The new approaches of modern anti-inflammatory therapy are based on
the synthesis of hydrogen sulfide-releasing hybrids of anti-inflammatory drugs or on the …
the synthesis of hydrogen sulfide-releasing hybrids of anti-inflammatory drugs or on the …