Naphthalimide derivatives with therapeutic characteristics: A patent review

A Kamal, NR Bolla, PS Srikanth… - Expert opinion on …, 2013 - Taylor & Francis
Introduction: Naphthalimides are important aromatic heterocycles with immense
pharmacological significance as they serve as core scaffold for many antitumor, anti …

1, 8‐Naphthalimide: a potent DNA intercalator and target for cancer therapy

R Tandon, V Luxami, H Kaur, N Tandon… - The Chemical …, 2017 - Wiley Online Library
The poor pharmacokinetics, side effects and particularly the rapid emergence of drug
resistance compromise the efficiency of clinically used anticancer drugs. Therefore, the …

Overview of naphthalimide analogs as anticancer agents

M Lv, H Xu - Current medicinal chemistry, 2009 - ingentaconnect.com
Cancer, which accounted for 7.9 million deaths (around 13% of all deaths) in 2007, is a
leading cause of death in the world. Deaths from cancer worldwide are projected to continue …

Synthesis and activities of naphthalimide azoles as a new type of antibacterial and antifungal agents

YY Zhang, CH Zhou - Bioorganic & medicinal chemistry letters, 2011 - Elsevier
Naphthalimide-derived azoles as a new type of antimicrobial agents were synthesized and
evaluated for their efficiency in vitro against eight bacteria and two fungi by two fold serial …

Naphthalimides in fluorescent imaging of tumor hypoxia–An up-to-date review

R Kumari, D Sunil, RS Ningthoujam - Bioorganic Chemistry, 2019 - Elsevier
Hypoxia is a distinctive characteristic of advanced solid malignancies that results from a
disparity between oxygen supply and its consumption. The degree of hypoxia is believed to …

A series of naphthalimide azoles: Design, synthesis and bioactive evaluation as potential antimicrobial agents

GLV Damu, QP Wang, HZ Zhang, YY Zhang… - Science China …, 2013 - Springer
A series of naphthalimide azoles as potential antibacterial and antifungal agents were
conveniently and efficiently synthesized starting from commercially available 6-bromobenzo …

Novel lead compounds in pre-clinical development against African sleeping sickness

M Berninger, I Schmidt, A Ponte-Sucre… - MedChemComm, 2017 - pubs.rsc.org
Human African trypanosomiasis (HAT), also known as African sleeping sickness, is caused
by parasitic protozoa of the genus Trypanosoma. As the disease progresses, the parasites …

Simultaneous staining of endoplasmic reticulum and lipid droplets by naphthol-aminonaphthalimide conjugates and photoinduced antiproliferative effects

M Sambol, M Košćak, L Uzelac, M Kralj, I Piantanida… - Dyes and pigments, 2022 - Elsevier
A detailed study of photophysical properties and photochemical reactivity of five novel
naphthol-aminonaphthalimide conjugates 1a-1e (differing in the linker length between two …

Synthesis, molecular modeling study, preliminary antibacterial, and antitumor evaluation of N-substituted naphthalimides and their structural analogues

AS El-Azab, AM Alanazi, NI Abdel-Aziz… - Medicinal Chemistry …, 2013 - Springer
Carboxylic acid imides 1–26 have been synthesized and screened for their antibacterial
against gram-positive and gram-negative organisms and their antitumor activity against 60 …

Copper (I) complexes with quinolone appended 1, 8-naphthalimide conjugates: structural characterization, DNA and protein binding and cytotoxicity studies

SA Shaikh, SS Bhat, VK Revankar, S Naveen… - New Journal of …, 2022 - pubs.rsc.org
A novel 1, 8-naphthalimide containing ligand (L) and its three mononuclear complexes with
different anions,[Cu (L) 2](NO3)· 3 (H2O)(1),[Cu (L) 2] Cl· 4 (H2O)(2),[Cu (L) 2] ClO4· DMF (3) …