Fibroblasts are highly dynamic cells that play a central role in tissue repair and fibrosis.
However, the mechanisms by which they contribute to both physiologic and pathologic …

Fibroblasts are diverse mesenchymal cells that participate in tissue homeostasis and
disease by producing complex extracellular matrix and creating signaling niches through …

Fibrosis can affect any organ and is responsible for up to 45% of all deaths in the
industrialized world. It has long been thought to be relentlessly progressive and irreversible …

Elevated liver de novo lipogenesis contributes to non-alcoholic steatohepatitis (NASH) and
can be inhibited by targeting acetyl-CoA carboxylase (ACC). However, hypertriglyceridemia …

Tubulointerstitial fibrosis is a chronic and progressive process affecting kidneys during aging
and in chronic kidney disease (CKD), regardless of cause. CKD and renal fibrosis affect half …

Fibrosis is the excessive accumulation of extracellular matrix that often occurs as a wound
healing response to repeated or chronic tissue injury, and may lead to the disruption of …

Transdifferentiation is a complete and stable change in cell identity that serves as an
alternative to stem-cell-mediated organ regeneration. In adult mammals, findings of …

Background & Aims Development of liver fibrosis is associated with activation of quiescent
hepatic stellate cells (HSCs) into collagen type I–producing myofibroblasts (activated HSCs) …

Neuroregeneration in the CNS has proven to be difficult despite decades of research. The
old dogma that CNS neurons cannot be regenerated in the adult mammalian brain has been …

Microvascular endothelial cells (ECs) are increasingly recognized as organ-specific
gatekeepers of their microenvironment. Microvascular ECs instruct neighboring cells in their …