Cyclooxygenases play a vital role in inflammation and are responsible for the production of
prostaglandins. Two cyclooxygenases are described, the constitutive cyclooxygenase-1 and …

Heterocyclic compounds are a class of compounds of natural origin with favorable
properties and hence have major pharmaceutical significance. They have an exceptional …

Lornoxicam (LRX) is a potent nonsteroidal anti-inflammatory drug (NSAID) used extensively
to manage pain and inflammatory conditions. However, the drug possesses poor aqueous …

Nitrogen heterocycles play an essential role in medication development. The 1, 2, 4‐
oxadiazole heterocycle has been extensively studied, yielding a large variety of molecules …

A new series of substituted aryl carboximidamide VIa-o was designed and synthesised. IR, 1
H NMR, 13 C NMR as well as elemental microanalysis were used to confirm the structures of …

The apoptotic antiproliferative actions of our previously reported CB1 allosteric modulators 5-
chlorobenzofuran-2-carboxamide derivatives VIIa–j prompted us to develop and synthesise …

In this article, we display on the synthesis and biological evaluation of a new series of
thiazolylpyrimidine 3a-l and thiazolidinylpyrimidine derivatives 5a-e. The structures of the …

A small set of indole-based derivatives, IV and Va–I, was designed and synthesized.
Compounds Va–i demonstrated promising antiproliferative activity, with GI50 values ranging …

Amino-5-formyluracil (1) was efficiently utilized for construction of a variety of novel
heteroannulated pyrimidines. Friedländer condensation reaction of compound 1 with some …

The investigation of novel EGFR and BRAFV600E dual inhibitors is intended to serve as
targeted cancer treatment. Two sets of purine/pteridine-based derivatives were designed …