Introduction Type II diabetes mellitus (T2DM) is a metabolic disorder that poses a serious
health concern worldwide due to its rising prevalence. Hypertension (HT) is a frequent …

Simple Summary Humanin is a small mitochondrial-derived peptide still under study, with a
number of potential therapeutic applications for various age-related diseases. It plays an …

Motivation Food-derived bioactive peptides (FBPs) have demonstrated their significance in
pharmaceuticals, diets and nutraceuticals, benefiting public health and global ecology …

Kruppel like factor 2 (KLF2) is a mechanosensitive transcription factor participating in the
regulation of vascular endothelial cells metabolism. Activating KLF2 in endothelial cells …

MOTS-c, a 16 amino acid mitochondrial derived peptide, is encoded from the 12S rRNA
region of the mitochondrial genome. Under stress conditions, MOTS-c translocates to the …

According to the latest Global Burden of Disease Study, cardiovascular disease (CVD) is the
leading cause of death, and ischemic heart disease and stroke are the cause of death in …

Abstract Background Mitochondria-derived peptides (MDPs) represent a recently discovered
family of peptides encoded by short open reading frames (ORFs) found within mitochondrial …

Inflammatory bowel disease (IBD) is a chronic and relapsing inflammatory disorder of the
gastrointestinal tract (GI). Currently, the treatment options for IBD are limited. It has been …

Intracerebral hemorrhage (ICH) is a severe, life-threatening subtype of stoke that constitutes
a crucial health and socioeconomic problem worldwide. However, the current clinical …

The peptides are known to have diverse therapeutic indications and help cure many disease
conditions. The mitochondrial genome comprises a novel class of micro peptides with …