Copper homeostasis and cuproptosis in health and disease
L Chen, J Min, F Wang - Signal transduction and targeted therapy, 2022 - nature.com
As an essential micronutrient, copper is required for a wide range of physiological processes
in virtually all cell types. Because the accumulation of intracellular copper can induce …
in virtually all cell types. Because the accumulation of intracellular copper can induce …
An overview of oxidative stress, neuroinflammation, and neurodegenerative diseases
DM Teleanu, AG Niculescu, II Lungu, CI Radu… - International journal of …, 2022 - mdpi.com
Oxidative stress has been linked with a variety of diseases, being involved in the debut
and/or progress of several neurodegenerative disorders. This review intends to summarize …
and/or progress of several neurodegenerative disorders. This review intends to summarize …
Oxidative stress and antioxidants in neurodegenerative disorders
EO Olufunmilayo, MB Gerke-Duncan, RMD Holsinger - Antioxidants, 2023 - mdpi.com
Neurodegenerative disorders constitute a substantial proportion of neurological diseases
with significant public health importance. The pathophysiology of neurodegenerative …
with significant public health importance. The pathophysiology of neurodegenerative …
Oxidative stress: The core pathogenesis and mechanism of Alzheimer's disease
As the number of patients with Alzheimer's disease (AD) increases, it brings great suffering
to their families and causes a heavy socioeconomic burden to society. A vast amount of …
to their families and causes a heavy socioeconomic burden to society. A vast amount of …
Twisted intramolecular charge transfer (TICT) and twists beyond TICT: from mechanisms to rational designs of bright and sensitive fluorophores
The twisted intramolecular charge transfer (TICT) mechanism has guided the development
of numerous bright and sensitive fluorophores. This review briefly overviews the history of …
of numerous bright and sensitive fluorophores. This review briefly overviews the history of …
The chemistry of reactive oxygen species (ROS) revisited: outlining their role in biological macromolecules (DNA, lipids and proteins) and induced pathologies
CA Juan, JM Pérez de la Lastra, FJ Plou… - International journal of …, 2021 - mdpi.com
Living species are continuously subjected to all extrinsic forms of reactive oxidants and
others that are produced endogenously. There is extensive literature on the generation and …
others that are produced endogenously. There is extensive literature on the generation and …
[HTML][HTML] Emerging roles of oxidative stress in brain aging and Alzheimer's disease
A Ionescu-Tucker, CW Cotman - Neurobiology of aging, 2021 - Elsevier
Reactive oxygen species (ROS) are metabolic byproducts that are necessary for
physiological function but can be toxic at high levels. Levels of these oxidative stressors …
physiological function but can be toxic at high levels. Levels of these oxidative stressors …
Challenges and hopes for Alzheimer's disease
SA Tatulian - Drug discovery today, 2022 - Elsevier
Recent drug development efforts targeting Alzheimer's disease (AD) have failed to produce
effective disease-modifying agents for many reasons, including the substantial …
effective disease-modifying agents for many reasons, including the substantial …
Oxidative stress mitigation by antioxidants-an overview on their chemistry and influences on health status
The present review paper focuses on the chemistry of oxidative stress mitigation by
antioxidants. Oxidative stress is understood as a lack of balance between the pro-oxidant …
antioxidants. Oxidative stress is understood as a lack of balance between the pro-oxidant …
[HTML][HTML] Mitochondrial dysfunction and oxidative stress in Alzheimer's disease
A Misrani, S Tabassum, L Yang - Frontiers in aging neuroscience, 2021 - frontiersin.org
Mitochondria play a pivotal role in bioenergetics and respiratory functions, which are
essential for the numerous biochemical processes underpinning cell viability. Mitochondrial …
essential for the numerous biochemical processes underpinning cell viability. Mitochondrial …