Spinal cord injury (SCI) constitutes an inestimable public health issue. The most crucial
phase in the pathophysiological process of SCI concerns the well-known secondary injury …

The discovery of mouse embryonic stem (ES) cells> 20 years ago represented a major
advance in biology and experimental medicine, as it enabled the routine manipulation of the …

Carcinoma-associated fibroblasts (CAFs) that express α-smooth muscle actin (αSMA)
contribute to cancer progression, but their precise origin and role are unclear. Using mouse …

The study of human cortical development has major implications for brain evolution and
diseases but has remained elusive due to paucity of experimental models. Here we found …

Poor survival of human embryonic stem (hES) cells after cell dissociation is an obstacle to
research, hindering manipulations such as subcloning. Here we show that application of a …

The potential of human embryonic stem (hES) cells to differentiate into cell types of a variety
of organs has generated much excitement over the possible use of hES cells in therapeutic …

We demonstrate directed differentiation of telencephalic precursors from mouse embryonic
stem (ES) cells using optimized serum-free suspension culture (SFEB culture). Treatment …

The hope of developing new transplantation therapies for degenerative diseases is limited
by inefficient stem cell growth and immunological incompatibility with the host,. Here we …

Bone fracture followed by delayed or non-union typically requires bone graft intervention.
Autologous bone grafts remain the clinical “gold standard”. Recently, synthetic bone grafts …

Human embryonic stem cells (hESCs) are routinely cultured on fibroblast feeder layers or in
fibroblast-conditioned medium (CM). Bone morphogenetic proteins (BMPs) have previously …