Red blood cells (RBC) are the most abundant cell in the human body, with a central role in
oxygen transport and its delivery to tissues. However, omics technologies recently revealed …

Tissue transglutaminase (TG2) is a widely distributed multifunctional protein involved in a
broad range of cellular and metabolic functions carried out in a variety of cellular …

The red blood cell (RBC)-Omics study, part of the larger NHLBI-funded Recipient
Epidemiology and Donor Evaluation Study (REDS-III), aims to understand the genetic …

Despite a wealth of exploratory plasma metabolomics studies in sickle cell disease (SCD),
no study to date has evaluate a large and well phenotyped cohort to compare the primary …

Mature red blood cells (RBCs) lack mitochondria and thus exclusively rely on glycolysis to
generate adenosine triphosphate (ATP) during aging in vivo or storage in blood banks …

Glioma stem cells (GSCs) in the hypoxic niches contribute to tumor initiation, progression,
and recurrence in glioblastoma (GBM). Hypoxia induces release of high-mobility group box …

Background: Blood transfusion is a life-saving intervention for millions of recipients
worldwide. Over the last 15 years, the advent of high-throughput, affordable omics …

Our aim is to present an updated overview of the erythrocyte metabolism highlighting its
richness and complexity. We have manually collected and connected the available …

Background The Red blood cell (RBC) storage lesion results in decreased circulation and
function of transfused RBCs. Elevated oxidant stress and impaired energy metabolism are a …

Background Even in the era of the COVID‐19 pandemic, trauma remains the global leading
cause of mortality under the age of 49. Trauma‐induced coagulopathy is a leading driver of …