The biology of YAP/TAZ: hippo signaling and beyond
S Piccolo, S Dupont, M Cordenonsi - Physiological reviews, 2014 - journals.physiology.org
The transcriptional regulators YAP and TAZ are the focus of intense interest given their
remarkable biological properties in development, tissue homeostasis and cancer. YAP and …
remarkable biological properties in development, tissue homeostasis and cancer. YAP and …
Competing endogenous RNA (ceRNA) cross talk and language in ceRNA regulatory networks: a new look at hallmarks of breast cancer
Breast cancer (BC) is the most frequently occurring malignancy in women worldwide.
Despite the substantial advancement in understanding the molecular mechanisms and …
Despite the substantial advancement in understanding the molecular mechanisms and …
[HTML][HTML] YAP1 and its fusion proteins in cancer initiation, progression and therapeutic resistance
YAP1 is a transcriptional co-activator whose activity is controlled by the Hippo signaling
pathway. In addition to important functions in normal tissue homeostasis and regeneration …
pathway. In addition to important functions in normal tissue homeostasis and regeneration …
[HTML][HTML] Polarity-dependent distribution of angiomotin localizes Hippo signaling in preimplantation embryos
Background In preimplantation mouse embryos, the first cell fate specification to the
trophectoderm or inner cell mass occurs by the early blastocyst stage. The cell fate is …
trophectoderm or inner cell mass occurs by the early blastocyst stage. The cell fate is …
Regulation of insulin-like growth factor signaling by Yap governs cardiomyocyte proliferation and embryonic heart size
The Hippo signaling pathway regulates growth of the heart and other tissues. Hippo
pathway kinases influence the activity of various targets, including the transcriptional …
pathway kinases influence the activity of various targets, including the transcriptional …
The LATS1 and LATS2 tumor suppressors: beyond the Hippo pathway
N Furth, Y Aylon - Cell Death & Differentiation, 2017 - nature.com
Proper cellular functionality and homeostasis are maintained by the convergent integration
of various signaling cascades, which enable cells to respond to internal and external …
of various signaling cascades, which enable cells to respond to internal and external …
DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly
L Litovchick, LA Florens, SK Swanson… - Genes & …, 2011 - genesdev.cshlp.org
In the absence of growth signals, cells exit the cell cycle and enter into G0 or quiescence.
Alternatively, cells enter senescence in response to inappropriate growth signals such as …
Alternatively, cells enter senescence in response to inappropriate growth signals such as …
A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis
T Azad, HJ Janse van Rensburg, ED Lightbody… - Nature …, 2018 - nature.com
The Hippo pathway is a central regulator of tissue development and homeostasis, and has
been reported to have a role during vascular development. Here we develop a …
been reported to have a role during vascular development. Here we develop a …
Upregulated long non-coding RNA AGAP2-AS1 represses LATS2 and KLF2 expression through interacting with EZH2 and LSD1 in non-small-cell lung cancer cells
Recently, long non-coding RNAs (lncRNAs) are identified as new crucial regulators of
diverse cellular processes, including cell proliferation, differentiation and cancer cells …
diverse cellular processes, including cell proliferation, differentiation and cancer cells …
SP1-induced upregulation of lncRNA SPRY4-IT1 exerts oncogenic properties by scaffolding EZH2/LSD1/DNMT1 and sponging miR-101-3p in cholangiocarcinoma
Y Xu, Y Yao, X Jiang, X Zhong, Z Wang, C Li… - Journal of Experimental …, 2018 - Springer
Background Accumulating evidence has indicated that long non-coding RNAs (lncRNAs)
behave as a novel class of transcription products during multiple cancer processes …
behave as a novel class of transcription products during multiple cancer processes …