Protein phosphorylation is a major regulator of protein function and biological outcomes.
This was first recognized through functional biochemical experiments, and in the past …

Many systems on our planet shift abruptly and irreversibly from the desired state to an
undesired state when forced across a “tipping point”. Some examples are mass extinctions …

When I am called upon to teach fluid mechanics, I always show students a copy of Newton's
Principia. I do this for a number of reasons, not least of which is the connection I hope they …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

One of the major challenges in modern biology is to understand how the molecular
components of a living cell operate in a highly noisy environment. What are the specific …

Summary The EGF-stimulated ERK/MAPK pathway is a key conduit for cellular proliferation
signals and a therapeutic target in many cancers. Here, we characterize two central …

Liquid–liquid phase separation (LLPS), a type of phase transition that is important in
organisms, is a unique means of forming biomolecular condensates. LLPS plays a …

The specificity of cellular responses to receptor stimulation is encoded by the spatial and
temporal dynamics of downstream signalling networks. Temporal dynamics are coupled to …

Background Asthma in a mouse model spontaneously resolves after cessation of allergen
exposure. We developed a mouse model in which asthma features persisted for 6 months …

Although we have amassed extensive catalogues of signalling network components, our
understanding of the spatiotemporal control of emergent network structures has lagged …