Heterocycles are common in the structure of drugs used clinically to deal with diseases.
Such drugs usually contain nitrogen, oxygen and sulfur, which possess electron-accepting …

Dementia represents a major problem of health and disability, with a relevant economic
impact on our society. Despite important advances in pathogenesis, diagnosis and …

In a search for new antioxidants, a set of new iodoquinazolinone derivatives bearing
benzenesulfonamide moiety and variable acetamide pharmacophores 5–17 were designed …

In this research, we have implemented two-dimensional quantitative structure-activity
relationship (2D-QSAR) modeling using two different datasets, namely, acetylcholinesterase …

A small library of molecules combining indolizine and N-alkyl pyridinium was synthesized
and evaluated in a multi-target-directed-ligand strategy for Alzheimer's disease (AD) …

Background: The treatment and diagnosis of Alzheimer's Disease (AD) are two of the most
urgent goals for research around the world. The cognitive decline is generally associated …

1, 8-Naphthyridine nucleus belongs to significant nitrogen-containing heterocyclic
compounds which has garnered the interest of researchers due to its versatile biological …

Background The loss of cholinergic neurotransmission in Alzheimer's disease (AD) patients'
brain is accompanied by a reduced concentration of Acetylcholine (ACh) within synaptic …

The present study describes the synthesis and characterization of a series of novel Schiff
bases derived from 2, 4-dihydroxybenzaldehyde. The biological activities of the newly …

Combining the pharmacological properties of the 1, 2, 3-triazole and dihydropyrimidinone
classes of compounds, two small families of mono-and di (1, 2, 3-triazole) …