A general introduction to glucocorticoid biology
S Timmermans, J Souffriau, C Libert - Frontiers in immunology, 2019 - frontiersin.org
Glucocorticoids (GCs) are steroid hormones widely used for the treatment of inflammation,
autoimmune diseases, and cancer. To exert their broad physiological and therapeutic …
autoimmune diseases, and cancer. To exert their broad physiological and therapeutic …
The nuclear receptor superfamily: A structural perspective
ER Weikum, X Liu, EA Ortlund - Protein Science, 2018 - Wiley Online Library
Nuclear receptors (NRs) are a family of transcription factors that regulate numerous
physiological processes such as metabolism, reproduction, inflammation, as well as the …
physiological processes such as metabolism, reproduction, inflammation, as well as the …
Structure of Hsp90–Hsp70–Hop–GR reveals the Hsp90 client-loading mechanism
RYR Wang, CM Noddings, E Kirschke, AG Myasnikov… - Nature, 2022 - nature.com
Maintaining a healthy proteome is fundamental for the survival of all organisms. Integral to
this are Hsp90 and Hsp70, molecular chaperones that together facilitate the folding …
this are Hsp90 and Hsp70, molecular chaperones that together facilitate the folding …
Structure of Hsp90–p23–GR reveals the Hsp90 client-remodelling mechanism
CM Noddings, RYR Wang, JL Johnson, DA Agard - Nature, 2022 - nature.com
Hsp90 is a conserved and essential molecular chaperone responsible for the folding and
activation of hundreds of 'client'proteins,–. The glucocorticoid receptor (GR) is a model client …
activation of hundreds of 'client'proteins,–. The glucocorticoid receptor (GR) is a model client …
Corticosteroids: mechanisms of action in health and disease
S Ramamoorthy, JA Cidlowski - Rheumatic Disease …, 2016 - rheumatic.theclinics.com
Corticosteroids are a class of steroid hormones released by the adrenal cortex, which
includes glucocorticoids and mineralocorticoids. 1 However, the term “corticosteroids” is …
includes glucocorticoids and mineralocorticoids. 1 However, the term “corticosteroids” is …
Glucocorticoid receptor control of transcription: precision and plasticity via allostery
ER Weikum, MT Knuesel, EA Ortlund… - … reviews Molecular cell …, 2017 - nature.com
The glucocorticoid receptor (GR) is a constitutively expressed transcriptional regulatory
factor (TRF) that controls many distinct gene networks, each uniquely determined by …
factor (TRF) that controls many distinct gene networks, each uniquely determined by …
Therapeutic glucocorticoids: mechanisms of actions in rheumatic diseases
Therapeutic glucocorticoids have been widely used in rheumatic diseases since they
became available over 60 years ago. Despite the advent of more specific biologic therapies …
became available over 60 years ago. Despite the advent of more specific biologic therapies …
The biology of the glucocorticoid receptor: new signaling mechanisms in health and disease
RH Oakley, JA Cidlowski - Journal of Allergy and Clinical Immunology, 2013 - Elsevier
Glucocorticoids are primary stress hormones necessary for life that regulate numerous
physiologic processes in an effort to maintain homeostasis. Synthetic derivatives of these …
physiologic processes in an effort to maintain homeostasis. Synthetic derivatives of these …
Treating the Side Effects of Exogenous Glucocorticoids; Can We Separate the Good From the Bad?
It is estimated that 2% to 3% of the population are currently prescribed systemic or topical
glucocorticoid treatment. The potent anti-inflammatory action of glucocorticoids to deliver …
glucocorticoid treatment. The potent anti-inflammatory action of glucocorticoids to deliver …
Nuclear receptor crosstalk—defining the mechanisms for therapeutic innovation
K De Bosscher, SJ Desmet, D Clarisse… - Nature Reviews …, 2020 - nature.com
Nuclear receptor crosstalk can be defined as the interplay between different nuclear
receptors or between their overlapping signalling pathways. A subset of nuclear receptors …
receptors or between their overlapping signalling pathways. A subset of nuclear receptors …