Glucocorticoids (GCs) are steroid hormones widely used for the treatment of inflammation,
autoimmune diseases, and cancer. To exert their broad physiological and therapeutic …

Nuclear receptors (NRs) are a family of transcription factors that regulate numerous
physiological processes such as metabolism, reproduction, inflammation, as well as the …

Maintaining a healthy proteome is fundamental for the survival of all organisms. Integral to
this are Hsp90 and Hsp70, molecular chaperones that together facilitate the folding …

Hsp90 is a conserved and essential molecular chaperone responsible for the folding and
activation of hundreds of 'client'proteins,–. The glucocorticoid receptor (GR) is a model client …

Corticosteroids are a class of steroid hormones released by the adrenal cortex, which
includes glucocorticoids and mineralocorticoids. 1 However, the term “corticosteroids” is …

The glucocorticoid receptor (GR) is a constitutively expressed transcriptional regulatory
factor (TRF) that controls many distinct gene networks, each uniquely determined by …

Therapeutic glucocorticoids have been widely used in rheumatic diseases since they
became available over 60 years ago. Despite the advent of more specific biologic therapies …

Glucocorticoids are primary stress hormones necessary for life that regulate numerous
physiologic processes in an effort to maintain homeostasis. Synthetic derivatives of these …

It is estimated that 2% to 3% of the population are currently prescribed systemic or topical
glucocorticoid treatment. The potent anti-inflammatory action of glucocorticoids to deliver …

Nuclear receptor crosstalk can be defined as the interplay between different nuclear
receptors or between their overlapping signalling pathways. A subset of nuclear receptors …