Pyruvate kinase M2 (PKM2) in cancer and cancer therapeutics
Abstract Pyruvate kinase M2 (PKM2), a key rate-limiting enzyme of glycolysis, is a critical
regulator in tumor metabolism. PKM2 has been demonstrated to overexpressed in various …
regulator in tumor metabolism. PKM2 has been demonstrated to overexpressed in various …
[HTML][HTML] Broad targeting of angiogenesis for cancer prevention and therapy
Deregulation of angiogenesis–the growth of new blood vessels from an existing vasculature–
is a main driving force in many severe human diseases including cancer. As such, tumor …
is a main driving force in many severe human diseases including cancer. As such, tumor …
Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance
L Leng, Z Yuan, R Pan, X Su, H Wang, J Xue… - Nature …, 2022 - nature.com
Microglial cells consume adenosine triphosphate (ATP) during phagocytosis to clear
neurotoxic β-amyloid in Alzheimer's disease (AD). However, the contribution of energy …
neurotoxic β-amyloid in Alzheimer's disease (AD). However, the contribution of energy …
Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation
How metabolism is reprogrammed during neuronal differentiation is unknown. We found that
the loss of hexokinase (HK2) and lactate dehydrogenase (LDHA) expression, together with …
the loss of hexokinase (HK2) and lactate dehydrogenase (LDHA) expression, together with …
Stem cell metabolism in tissue development and aging
Recent advances in metabolomics and computational analysis have deepened our
appreciation for the role of specific metabolic pathways in dictating cell fate. Once thought to …
appreciation for the role of specific metabolic pathways in dictating cell fate. Once thought to …
Dengue virus induces and requires glycolysis for optimal replication
KA Fontaine, EL Sanchez, R Camarda… - Journal of …, 2015 - Am Soc Microbiol
Viruses rely on host cellular metabolism to provide the energy and biosynthetic building
blocks required for their replication. Dengue virus (DENV), a member of the Flaviviridae …
blocks required for their replication. Dengue virus (DENV), a member of the Flaviviridae …
AMPK is essential to balance glycolysis and mitochondrial metabolism to control T-ALL cell stress and survival
RJ Kishton, CE Barnes, AG Nichols, S Cohen… - Cell metabolism, 2016 - cell.com
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy associated with
Notch pathway mutations. While both normal activated and leukemic T cells can utilize …
Notch pathway mutations. While both normal activated and leukemic T cells can utilize …
Lnc RNA wires up Hippo and Hedgehog signaling to reprogramme glucose metabolism
X Zheng, H Han, GP Liu, YX Ma, RL Pan… - The EMBO …, 2017 - embopress.org
The Hippo pathway plays essential roles in organ size control and cancer prevention via
restricting its downstream effector, Yes‐associated protein (YAP). Previous studies have …
restricting its downstream effector, Yes‐associated protein (YAP). Previous studies have …
NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity
Metabolic reprograming toward aerobic glycolysis is a pivotal mechanism shaping immune
responses. Here we show that deficiency in NF-κB-inducing kinase (NIK) impairs glycolysis …
responses. Here we show that deficiency in NF-κB-inducing kinase (NIK) impairs glycolysis …
Hexokinase 2 promotes tumor growth and metastasis by regulating lactate production in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is a KRAS-driven cancer with a high incidence
of metastasis and an overall poor prognosis. Previous work in a genetically engineered …
of metastasis and an overall poor prognosis. Previous work in a genetically engineered …