α1‐Adrenoceptors are seven transmembrane domain GPCRs involved in numerous
physiological functions controlled by the endogenous catecholamines, noradrenaline and …

The G protein-coupled receptors form the most abundant family of membrane proteins and
are crucial physiologic players in the homeostatic equilibrium, which we define as health …

β-Arrestins are key regulators and signal transducers of G protein–coupled receptors
(GPCRs). The interaction between receptors and β-arrestins is generally believed to require …

The developmental process of central nervous system (CNS) myelin sheath formation is
characterized by well‐coordinated cellular activities ultimately ensuring rapid and …

The G protein-coupled receptors (GPCRs) are plasma membrane proteins that function as
sensors of changes in the internal and external milieux and play essential roles in health …

A multitude of physiological processes regulated by G protein-coupled receptors (GPCRs)
signaling are accomplished by the participation of active rearrangements of the …

Sphingosine 1-phosphate (S1P) and FTY720-phosphate (FTYp) increased intracellular
calcium in cells expressing S1P1 mCherry-tagged receptors; the synthetic agonist was …

Results The lysophosphatidic acid receptors LPA1, LPA2, and LPA3 were individually
expressed in C9 cells and their signaling and regulation were studied. Agonist-activation …

ABSTRACT G protein-coupled receptors (GPCRs) constitute a superfamily of cell surface
receptors that regulate a variety of cell functions. As the cell surface is the functional …

Alpha-1 adrenoceptors are overexpressed in the epidermis of a subgroup of patients with
complex regional pain syndrome (CRPS). Activating a1-adrenoceptors in epidermal cells …