The skeleton is diverse in its functions, which include mechanical support, movement, blood
cell production, mineral storage and endocrine regulation. This multifaceted role is achieved …

The development of interdisciplinary biomedical engineering brings significant
breakthroughs to the field of cartilage regeneration. However, cartilage defects are …

Cartilage is essential throughout vertebrate life. It starts developing in embryos when
osteochondroprogenitor cells commit to chondrogenesis, activate a pancartilaginous …

Osteoblasts are the only cells that can give rise to bones in vertebrates. Thus, one of the
most important functions of these metabolically active cells is mineralized matrix production …

Hypertrophic chondrocytes are the master regulators of endochondral ossification; however,
their ultimate cell fates cells remain largely elusive due to their transient nature. Historically …

The resting zone of the postnatal growth plate is organized by slow-cycling chondrocytes
expressing parathyroid hormone-related protein (PTHrP), which include a subgroup of …

Amino acid metabolism regulates essential cellular functions, not only by fueling protein
synthesis, but also by supporting the biogenesis of nucleotides, redox factors and lipids …

The majority of the mammalian skeleton is formed through endochondral ossification starting
from a cartilaginous template. Cartilage cells, or chondrocytes, survive, proliferate and …

The sea cucumber intestine is a major by-product of sea cucumber processing and contains
high levels of protein. In this study, we isolated and identified 28 novel osteogenic peptides …

The secretome of mesenchymal stromal cells (MSCs) derived from different tissue sources is
considered an innovative therapeutic tool for regenerative medicine. Although adipose …