Inhibitors of HSP90 in melanoma
A Mielczarek-Lewandowska, ML Hartman, M Czyz - Apoptosis, 2020 - Springer
Abstract HSP90 (heat shock protein 90) is an ATP-dependent molecular chaperone involved
in a proper folding and maturation of hundreds of proteins. HSP90 is abundantly expressed …
in a proper folding and maturation of hundreds of proteins. HSP90 is abundantly expressed …
17-Aminogeldanamycin selectively diminishes IRE1α-XBP1s pathway activity and cooperatively induces apoptosis with MEK1/2 and BRAFV600E inhibitors in …
A Mielczarek-Lewandowska, M Sztiller-Sikorska… - Apoptosis, 2019 - Springer
Outcomes of melanoma patient treatment remain unsatisfactory despite accessibility of
oncoprotein-targeting drugs and immunotherapy. Here, we reported that 17 …
oncoprotein-targeting drugs and immunotherapy. Here, we reported that 17 …
[HTML][HTML] A stemness and EMT based gene expression signature identifies phenotypic plasticity and is a predictive but not prognostic biomarker for breast cancer
Aims: Molecular heterogeneity of breast cancer results in variation in morphology, metastatic
potential and response to therapy. We previously showed that breast cancer cell line sub …
potential and response to therapy. We previously showed that breast cancer cell line sub …
Predictive gene signature for pyrazolopyrimidine derivative c-Src inhibitor 10a sensitivity in melanoma cells
B Kucukkaraduman, C Turk, AL Fallacara… - ACS Medicinal …, 2020 - ACS Publications
Melanoma is a highly aggressive cancer with poor prognosis. Although more than 80% of
melanomas harbor an activating mutation in genes within the MAPK pathway, which are …
melanomas harbor an activating mutation in genes within the MAPK pathway, which are …
Multiomics Approaches to Overcome Drug Resistance in Cancer
B Küçükkaraduman - 2021 - search.proquest.com
Chemotherapy resistance remains one of the major challenges in cancer treatment. Most of
the studies on drug resistance have focused on genetic evolution of cancer cells; however …
the studies on drug resistance have focused on genetic evolution of cancer cells; however …
Prediction of Prognosis and Chemosensitivity in Breast Cancer
MW Akbar - 2020 - search.proquest.com
Breast cancer (BC) is responsible for the highest mortality and morbidity out of all the
cancers in women which is primarily due to both inter and intra-tumoral molecular …
cancers in women which is primarily due to both inter and intra-tumoral molecular …
Inhibitors of HSP90 in melanoma
ML Aleksandra, ML Hartman… - … An International Journal …, 2020 - search.proquest.com
Abstract HSP90 (heat shock protein 90) is an ATP-dependent molecular chaperone involved
in a proper folding and maturation of hundreds of proteins. HSP90 is abundantly expressed …
in a proper folding and maturation of hundreds of proteins. HSP90 is abundantly expressed …
[PDF][PDF] Designing effective lead molecules against solid tumors with inadequate treatment options, the efficacy problem
T Pantsar - 2018 - dspace.uef.fi
Hepatocellular carcinoma (HCC) is a lethal disease with a poor prognosis. It is the sixth most
common cancer in the world with high mortality; it is the third leading cause of death of all …
common cancer in the world with high mortality; it is the third leading cause of death of all …