The progressive loss of skeletal muscle mass and concomitant reduction in contractile
strength plays a central role in frailty syndrome. Age-related neuronal impairments are …

Two‐dimensional gel electrophoresis (2‐DE) is widely applied and remains the method of
choice in proteomics; however, pervasive 2‐DE‐related concerns undermine its prospects …

Cancer-associated fibroblasts (CAFs) drive tumour progression, but the emergence of this
cell state is poorly understood. A broad spectrum of metalloproteinases, controlled by the …

The multiplexing capabilities of isobaric mass tag-based protein quantification, such as
Tandem Mass Tags or Isobaric Tag for Relative and Absolute Quantitation have dramatically …

The advent of reprogramming and its impact on stem cell biology has renewed interest in
lineage restriction in mammalian embryos, the source of embryonic (ES), epiblast (EpiSC) …

The analysis of proteins in biological membranes forms a major challenge in proteomics.
Despite continuous improvements and the development of more sensitive analytical …

The emergence of shotgun proteomics has facilitated the numerous biological discoveries
made by proteomic studies. However, comprehensive proteomic analysis remains …

Background Skeletal muscle fibres represent one of the most abundant cell types in
mammals. Their highly specialised contractile and metabolic functions depend on a large …

Over the past century, the significance of the rhizosphere has been increasingly recognized
by the scientific community. This complex biological system is comprised of vast …

The purpose of clinical proteomics is to characterise protein profiles of a plethora of
diseases with the aim of finding specific biomarkers. These are particularly valuable for early …