Treatments for depression have improved, and their availability has markedly increased
since the 1980s. Mysteriously the general population prevalence of depression has not …

The role of serotonin in depression and antidepressant treatment remains unresolved
despite decades of research. In this paper, we make three major claims. First, serotonin …

Major depressive disorder (MDD) is highly disabling and typically runs a recurrent course.
Knowledge about prevention of relapse and recurrence is crucial to the long-term welfare of …

Long-term antidepressant treatment has increased and there is evidence of adverse effects;
however, little is known about patients' experiences and views of this form of treatment. This …

Context Mindfulness-based cognitive therapy (MBCT) is a group-based psychosocial
intervention designed to enhance self-management of prodromal symptoms associated with …

ABSTRACT A specific psychotherapeutic strategy for increasing psychological well‐being
and resilience, well‐being therapy, has been developed and validated in a number of …

Background: This paper examines the current status of research on the efficacy and
effectiveness of antidepressants. Methods: This paper reviews four meta-analyses of efficacy …

Chronic stress has been shown in animal models to result in altered dendritic morphology of
pyramidal neurons of the medial prefrontal cortex (mPFC). It has been hypothesized that the …

Background Major depression is probably best seen as a chronically recurrent disorder, with
patients experiencing another depressive episode after remission. Therefore, attention to …

Depression is an important target of psychological assessment in patients with end-stage
renal disease because it predicts their morbidity, mortality, and quality of life. We assessed …