Osteoarthritis (OA) is a long-term condition that causes joint pain and reduced movement.
Notably, the same pathways governing cell growth, death, and differentiation during the …

Epigenetic mechanisms guiding articular cartilage regeneration and age‐related disease
such as osteoarthritis (OA) are poorly understood. STAT3 is a critical age‐patterned …

Fracture healing is a complex event that involves the coordination of various different
processes, including intramembranous and endochondral bone formation. When facing …

Autologous blood-derived products such as platelet-rich plasma (PRP) are widely used to
treat musculoskeletal conditions, including knee osteoarthritis (OA). However, the clinical …

Background Methylation at cytosines (mCG) is a well-known regulator of gene expression,
but its requirements for cellular differentiation have yet to be fully elucidated. A well-studied …

In osteoarthritis (OA), articular chondrocytes display phenotypic and functional changes
associated with epigenomic alterations. These changes contribute to the disease …

Epigenetic modifications play critical roles in regulating cell lineage differentiation, but the
epigenetic mechanisms guiding specific differentiation steps within a cell lineage have …

Cartilage tissue is comprised of extracellular matrix and chondrocytes, a cell type with very
low cellular turnover in adults, providing limited capacity for regeneration. However, in …

Growth of the axial and appendicular skeleton depends on endochondral ossification, which
is controlled by tightly regulated cell–cell interactions in the developing growth plates …

Knee osteoarthritis (OA) involves complex and heterogeneous changes to articular cartilage
(AC), with morphologically-and molecularly-distinct regions presenting simultaneously. The …