Primary cilia project in a single copy from the surface of most vertebrate cell types; they
detect and transmit extracellular cues to regulate diverse cellular processes during …

The ability to detect stimuli from the environment plays a pivotal role in our survival. The
molecules that allow the detection of such signals include ion channels, which are proteins …

The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Abstract The TRP (Transient Receptor Potential) superfamily of cation channels is
remarkable in that it displays greater diversity in activation mechanisms and selectivities …

Transient receptor potential (TRP) channels are a large family of ion channel proteins,
surpassed in number in mammals only by voltage-gated potassium channels. TRP channels …

Mutations in the polycystin genes, PKD1 or PKD2, results in Autosomal Dominant Polycystic
Kidney Disease (ADPKD). Although a genetic basis of ADPKD is established, we lack a …

WNT ligands induce Ca2+ signalling on target cells. PKD1 (polycystin 1) is considered an
orphan, atypical G-protein-coupled receptor complexed with TRPP2 (polycystin 2 or PKD2) …

When we edited in 2007 the first issue on transient receptor potential channel in the
Handbook of Experimental Pharmacology, we were all very excited by the progress in this …

Primary cilia have been proposed to participate in the modulation of growth factor signaling
pathways. In this study, we determined that ciliogenesis is suppressed in both pancreatic …