N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels widely
expressed in the central nervous system that play key role in brain development and …

Dopamine (DA) is a critical neuromodulator involved in various brain functions. To
understand how DA regulates neural circuits and behaviors in the physiological and …

Several trace metals, including iron, copper, manganese and zinc are essential for normal
function of the nervous system. Both deficiency and excessive accumulation of these metals …

Flavin-based fluorescent proteins (FbFPs) are a class of fluorescent reporters that undergo
oxygen-independent fluorophore incorporation, which is an important advantage over green …

Exposure to loud noise triggers sensory organ damage and degeneration that, in turn, leads
to hearing loss. Despite the troublesome impact of noise-induced hearing loss (NIHL) in …

Red fluorescent protein (RFP) derived indicators are popular due to advantages such as
increased imaging depth and reduced autofluorescence and cytotoxicity. However, most …

A two-photon near infrared (NIR) fluorescence turn-on sensor with high selectivity and
sensitivity for Zn 2+ detection has been developed. This sensor exhibits a large Stokes' shift …

Genetically encoded fluorescent metal ion sensors are powerful tools for elucidating metal
dynamics in living systems. Over the last 25 years since the first examples of genetically …

In addition to the essential structural and catalytic functions of zinc, evolution has adopted
synaptic zinc as a neuromodulator. In the brain, synaptic zinc is released from primarily …

Depressive disorders are a common and debilitating form of mental illness with significant
impacts on individuals and society. Despite the high prevalence, the underlying causes and …