Targeting the latent reservoir for HIV-1
S Sengupta, RF Siliciano - Immunity, 2018 - cell.com
Antiretroviral therapy can effectively block HIV-1 replication and prevent or reverse
immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within …
immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within …
HIV latency
RF Siliciano, WC Greene - Cold Spring …, 2011 - perspectivesinmedicine.cshlp.org
HIV-1 can establish a state of latent infection at the level of individual T cells. Latently
infected cells are rare in vivo and appear to arise when activated CD4+ T cells, the major …
infected cells are rare in vivo and appear to arise when activated CD4+ T cells, the major …
The latent reservoir of inducible, infectious HIV-1 does not decrease despite decades of antiretroviral therapy
NF McMyn, J Varriale, EJ Fray… - The Journal of …, 2023 - Am Soc Clin Investig
HIV-1 persists in a latent reservoir in resting CD4+ T cells despite antiretroviral therapy
(ART). The reservoir decays slowly over the first 7 years of ART (t 1/2= 44 months). However …
(ART). The reservoir decays slowly over the first 7 years of ART (t 1/2= 44 months). However …
Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells
JB McBrien, M Mavigner, L Franchitti, SA Smith… - Nature, 2020 - nature.com
Human immunodeficiency virus (HIV) persists indefinitely in individuals with HIV who
receive antiretroviral therapy (ART) owing to a reservoir of latently infected cells that contain …
receive antiretroviral therapy (ART) owing to a reservoir of latently infected cells that contain …
Precise quantitation of the latent HIV-1 reservoir: implications for eradication strategies
AM Crooks, R Bateson, AB Cope… - The Journal of …, 2015 - academic.oup.com
The quantitative viral outgrowth assay (QVOA) provides a precise minimal estimate of the
reservoir of resting CD4+ T-cell infection (resting cell infection [RCI]). However, the variability …
reservoir of resting CD4+ T-cell infection (resting cell infection [RCI]). However, the variability …
Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies
HIV-1 reservoirs preclude virus eradication in patients receiving highly active antiretroviral
therapy (HAART). The best characterized reservoir is a small, difficult-to-quantify pool of …
therapy (HAART). The best characterized reservoir is a small, difficult-to-quantify pool of …
Inflammatory and coagulation biomarkers and mortality in patients with HIV infection
Background In the Strategies for Management of Anti-Retroviral Therapy trial, all-cause
mortality was higher for participants randomized to intermittent, CD4-guided antiretroviral …
mortality was higher for participants randomized to intermittent, CD4-guided antiretroviral …
Inflammation, immune activation, and antiretroviral therapy in HIV
CO Hileman, NT Funderburg - Current Hiv/aids reports, 2017 - Springer
Abstract Purpose of Review This review focuses on the differential effects of contemporary
antiretrovirals on systemic inflammation as heightened immune activation is linked to …
antiretrovirals on systemic inflammation as heightened immune activation is linked to …
The challenge of finding a cure for HIV infection
Although combination therapy for HIV infection represents a triumph for modern medicine,
chronic suppressive therapy is required to contain persistent infection in reservoirs such as …
chronic suppressive therapy is required to contain persistent infection in reservoirs such as …
HIV and inflammation: mechanisms and consequences
PW Hunt - Current HIV/AIDS Reports, 2012 - Springer
Persistent immune activation and inflammation despite sustained antiretroviral therapy
(ART)-mediated viral suppression has emerged as a major challenge of the modern HIV …
(ART)-mediated viral suppression has emerged as a major challenge of the modern HIV …