Rap1 regulates apical contractility to allow embryonic morphogenesis without tissue disruption and acts in part via Canoe-independent mechanisms
KZ Perez-Vale, KD Yow, NJ Gurley… - Molecular Biology of …, 2023 - Am Soc Cell Biol
Embryonic morphogenesis is powered by dramatic changes in cell shape and arrangement
driven by the cytoskeleton and its connections to adherens junctions. This requires robust …
driven by the cytoskeleton and its connections to adherens junctions. This requires robust …
Interactions between Ras and Rap signaling pathways during neurodevelopment in health and disease
SJ Cherra III, R Lamb - Frontiers in Molecular Neuroscience, 2024 - frontiersin.org
The Ras family of small GTPases coordinates tissue development by modulating cell
proliferation, cell-cell adhesion, and cellular morphology. Perturbations of any of these key …
proliferation, cell-cell adhesion, and cellular morphology. Perturbations of any of these key …
Shank2 binds to aPKC and controls tight junction formation with Rap1 signaling during establishment of epithelial cell polarity
K Sasaki, N Kojitani, H Hirose, Y Yoshihama, H Suzuki… - Cell reports, 2020 - cell.com
Epithelial cells establish apicobasal polarity by forming tight junctions (TJs) at the apical-
lateral boundary, which play fundamental roles in physiological functions. An evolutionarily …
lateral boundary, which play fundamental roles in physiological functions. An evolutionarily …
Loss of p21-activated kinase Mbt/PAK4 causes Parkinson-like phenotypes in Drosophila
SM Pütz, J Kram, E Rauh, S Kaiser… - Disease models & …, 2021 - journals.biologists.com
Parkinson's disease (PD) provokes bradykinesia, resting tremor, rigidity and postural
instability, and also non-motor symptoms such as depression, anxiety, sleep and cognitive …
instability, and also non-motor symptoms such as depression, anxiety, sleep and cognitive …
Chronic exposure to titanium dioxide nanoparticles induces deficits of locomotor behavior by disrupting the development of NMJ in Drosophila
X Zhang, Y Song, J Wang, C Wu, H Xiang, J Hu… - Science of The Total …, 2023 - Elsevier
Abstract Titanium dioxide nanoparticles (TiO 2 NPs) are widely used in several consumer
products. However, because of their neurotoxic nature, exposure to TiO 2 NPs could impair …
products. However, because of their neurotoxic nature, exposure to TiO 2 NPs could impair …
PXF-1 promotes synapse development at the neuromuscular junction in Caenorhabditis elegans
R Lamb, B Dhar, SJ Cherra III - Frontiers in Molecular Neuroscience, 2022 - frontiersin.org
Guanine nucleotide exchange factors (GEFs) are a family of proteins that modulate small G
protein signaling. Mutations in a subfamily of GEFs that act on Rap, known as RapGEFs …
protein signaling. Mutations in a subfamily of GEFs that act on Rap, known as RapGEFs …
Investigation of the Structure-function Relationship of the PDZ G-nucleotide Exchange Factor (PDZ-GEF) Dizzy in Drosophila
A Witz - 2023 - tobias-lib.ub.uni-tuebingen.de
The migration of embryonic macrophages in the fruit fly is an ideal system to investigate the
regulation and the mechanisms of cell movement in vivo. The macrophages originate from …
regulation and the mechanisms of cell movement in vivo. The macrophages originate from …
Rap1 uses Canoe-dependent and Canoe-independent mechanisms to regulate apical contractility and allow embryonic morphogenesis without tissue disruption
KZ Perez-Vale, KD Yow, M Greene, NJ Gurley, M Peifer - bioRxiv, 2022 - biorxiv.org
Embryonic morphogenesis is powered by dramatic changes in cell shape and arrangement,
driven by the cytoskeleton and its connections to adherens junctions. This requires robust …
driven by the cytoskeleton and its connections to adherens junctions. This requires robust …
NC 27599-3280, USA
KZ Perez-Vale, KD Yow, NJ Gurley, M Greene - Am Soc Cell Biol
Embryonic morphogenesis is powered by dramatic changes in cell shape and arrangement,
driven by the cytoskeleton and its connections to adherens junctions. This requires robust …
driven by the cytoskeleton and its connections to adherens junctions. This requires robust …