The nucleus, a genome-containing organelle eponymous of eukaryotes, is enclosed by a
double membrane continuous with the endoplasmic reticulum. The nuclear pore complex …

Nuclear pore complexes (NPCs) are the only transport channels that cross the nuclear
envelope. Constructed from~ 500–1000 nucleoporin proteins each, they are among the …

Nuclear pore complexes (NPCs) create large conduits for cargo transport between the
nucleus and cytoplasm across the nuclear envelope (NE),–. These multi-megadalton …

INTRODUCTION Cytoplasmic face of the human NPC. Near-atomic composite structure of
the NPC generated by docking high-resolution crystal structures into a cryo‑ET …

INTRODUCTION In eukaryotic cells, the selective bidirectional transport of macromolecules
between the nucleus and cytoplasm occurs through the nuclear pore complex (NPC) …

Expansion microscopy (ExM) is in increasingly widespread use throughout biology because
its isotropic physical magnification enables nanoimaging on conventional microscopes. To …

The nuclear envelope, which protects and organizes the genome, is dismantled during
mitosis. In the Caenorhabditis elegans zygote, nuclear envelope breakdown (NEBD) of the …

Developing effective treatments for neurodegenerative diseases such as amyotrophic lateral
sclerosis (ALS) requires understanding of the underlying pathomechanisms that contribute …

A journey from the earliest known use of lenses and magnifying glasses in ancient times,
through the development of microscopes and towards modern electron microscopy …

Phase separation forms membraneless compartments in the nuclei, including by
establishing heterochromatin “domains” and repair foci. Pericentromeric heterochromatin …