Matrigel: from discovery and ECM mimicry to assays and models for cancer research
G Benton, I Arnaoutova, J George, HK Kleinman… - Advanced drug delivery …, 2014 - Elsevier
The basement membrane is an important extracellular matrix that is found in all epithelial
and endothelial tissues. It maintains tissue integrity, serves as a barrier to cells and to …
and endothelial tissues. It maintains tissue integrity, serves as a barrier to cells and to …
CXCR4 downregulation of let-7a drives chemoresistance in acute myeloid leukemia
Y Chen, R Jacamo, M Konopleva… - The Journal of …, 2013 - Am Soc Clin Investig
We examined the role of microRNAs (miRNAs) in targeting the stromal-derived factor
1α/CXCR4 (SDF-1α/CXCR4) axis to overcome chemoresistance of AML cells. Microarray …
1α/CXCR4 (SDF-1α/CXCR4) axis to overcome chemoresistance of AML cells. Microarray …
Molecular alterations as target for therapy in metastatic osteosarcoma: a review of literature
J PosthumaDeBoer, MA Witlox, GJL Kaspers… - Clinical & experimental …, 2011 - Springer
Treating metastatic osteosarcoma (OS) remains a challenge in oncology. Current treatment
strategies target the primary tumour rather than metastases and have a limited efficacy in the …
strategies target the primary tumour rather than metastases and have a limited efficacy in the …
Dissecting the roles and clinical potential of YY1 in the tumor microenvironment
MN Li, JX Wei, CN Xue, XT Zhou, SP Chen… - Frontiers in …, 2023 - frontiersin.org
Yin-Yang 1 (YY1) is a member of the GLI-Kruppel family of zinc finger proteins and plays a
vital dual biological role in cancer as an oncogene or a tumor suppressor during …
vital dual biological role in cancer as an oncogene or a tumor suppressor during …
Biomarkers of osteosarcoma, chondrosarcoma, and Ewing sarcoma
Osteosarcoma is the most frequent malignant bone neoplasm, followed by chondrosarcoma
and Ewing sarcoma. The diagnosis of bone neoplasms is generally made through …
and Ewing sarcoma. The diagnosis of bone neoplasms is generally made through …
The oncogenic role of Yin Yang 1
ABSTRACT Yin Yang 1 (YY1) is a transcription factor with diverse and complex biological
functions. YY1 either activates or represses gene transcription, depending on the stimuli …
functions. YY1 either activates or represses gene transcription, depending on the stimuli …
KRAS/NF-κB/YY1/miR-489 signaling axis controls pancreatic cancer metastasis
P Yuan, XH He, YF Rong, J Cao, Y Li, YP Hu, Y Liu… - Cancer research, 2017 - AACR
KRAS activation occurring in more than 90% of pancreatic ductal adenocarcinomas (PDAC)
drives progression and metastasis, but the underlying mechanisms involved in these …
drives progression and metastasis, but the underlying mechanisms involved in these …
Sarcoma spheroids and organoids—promising tools in the era of personalized medicine
Cancer treatment is rapidly evolving toward personalized medicine, which takes into
account the individual molecular and genetic variability of tumors. Sophisticated new in vitro …
account the individual molecular and genetic variability of tumors. Sophisticated new in vitro …
Yin Yang-1 suppresses invasion and metastasis of pancreatic ductal adenocarcinoma by downregulating MMP10 in a MUC4/ErbB2/p38/MEF2C-dependent …
JJ Zhang, Y Zhu, KL Xie, YP Peng, JQ Tao, J Tang, Z Li… - Molecular cancer, 2014 - Springer
Background Increasing evidence indicates an important role of transcription factor Yin Yang-
1 (YY1) in human tumorigenesis. However, its function in cancer remains controversial and …
1 (YY1) in human tumorigenesis. However, its function in cancer remains controversial and …