The MYC proto-oncogenes encode a family of transcription factors that are among the most
commonly activated oncoproteins in human neoplasias. Indeed, MYC aberrations or …

The proteins extracellular signal-regulated kinase 1 (ERK1) and ERK2 are the downstream
components of a phosphorelay pathway that conveys growth and mitogenic signals largely …

Although the MYC oncogene has been implicated in cancer, a systematic assessment of
alterations of MYC, related transcription factors, and co-regulatory proteins, forming the …

Cancer is a multistep disease driven by the activation of specific oncogenic pathways
concomitantly with the loss of function of tumor suppressor genes that act as sentinels to …

Two opposing models have been proposed to describe the function of the MYC oncoprotein
in shaping cellular transcriptomes: one posits that MYC amplifies transcription at all active …

The insect fat body is analogous to vertebrate adipose tissue and liver. In this review, the
new and exciting advancements made in fat body biology in the last decade are …

The control of body and organ growth is essential for the development of adults with proper
size and proportions, which is important for survival and reproduction. In animals, adult body …

The MYC proto-oncogene is frequently activated in human cancers through a variety of
mechanisms. Its deregulated expression, unconstrained by inactivation of key checkpoints …

Reprogramming of cellular metabolism is a key event during tumorigenesis. Despite being
known for decades (Warburg effect), the molecular mechanisms regulating this switch …

An adult animal consists of cells of vastly different size and activity, but the regulation of cell
size remains poorly understood. Recent studies uncovering some of the signaling pathways …