“Frailty” is a term used to refer to a state characterized by enhanced vulnerability to, and
impaired recovery from, stressors compared with a nonfrail state, which is increasingly …

Cerebral autoregulation (CA) refers to the control of cerebral tissue blood flow (CBF) in
response to changes in perfusion pressure. Due to the challenges of measuring intracranial …

Mice with insulin receptor (IR)–deficient astrocytes (GFAP-IR knockout [KO] mice) show
blunted responses to insulin and reduced brain glucose uptake, whereas IR-deficient …

Microglia are the resident immune cells of the central nervous system contributing
substantially to health and disease. There is increasing evidence that inflammatory microglia …

Dynamic cerebral autoregulation (dCA) is a key mechanism that regulates cerebral blood
flow (CBF) in response to transient changes in blood pressure (BP). Impairment of dCA …

Circadian and diurnal variation in cerebral blood flow directly contributes to the diurnal
variation in the risk of stroke, either through factors that trigger stroke or due to impaired …

Neurovascular coupling (NVC) is the matching between local neuronal activity and regional
cerebral blood flow (CBF), but little is known about the effects of age and sex on NVC. This …

Sport-related concussion (SRC) can impair the cerebrovasculature both acutely and
chronically. Transcranial Doppler (TCD) ultrasound assessment has the potential to …

The microvasculature plays a key role in oxygen transport in the mammalian brain. Despite
the close coupling between cerebral vascular geometry and local oxygen demand, recent …

Background Since arterial flow is the leading actor in neuro-fluids flow dynamics, it might be
interesting to assess whether it is meaningful to study the arterial flow waveform in more …