Acromegaly is a chronic systemic disease with many complications and is associated with
increased mortality when not adequately treated. Substantial advances in acromegaly …

Growth hormone (GH) and insulin-like growth factor 1 (IGF1) are important regulators of
bone remodelling and metabolism and have an essential role in the achievement and …

Purpose Bone is one of the main targets of hormones and endocrine diseases are frequent
causes of secondary osteoporosis and fractures in real-world clinical practice. However …

Background. Growth hormone (GH) and insulin‐like growth factor (IGF‐1) are fundamental
in skeletal growth during puberty and bone health throughout life. GH increases tissue …

Abstract More than 2.1 million age-related fractures occur in the United States annually,
resulting in an immense socioeconomic burden. Importantly, the age-related deterioration of …

Context: GH excess causes an increase in bone turnover, but the consequences in terms of
skeletal fragility have long been uncertain due to the heterogeneity of studies dealing with …

Neuroendocrinology of bone is a new area of research based on the evidence that pituitary
hormones may directly modulate bone remodeling and metabolism. Skeletal fragility …

Context: Cross-sectional studies showed an elevated prevalence of vertebral fractures in
acromegaly. However, no data are available on incident vertebral fractures in this clinical …

Diabetes mellitus is a frequent complication of acromegaly, a disease characterized by
chronic hypersecretion of growth hormone (GH) by a pituitary adenoma. Diabetes occurs …

Objective: Pituitary adenomas are the third most common central nervous system tumors
and arise from the anterior pituitary within the pituitary fossa. Methods: Literature review and …