Amongst the lysosomal cysteine cathepsin family of proteases, cathepsin S (CTSS) holds
particular interest due to distinctive properties including a normal restricted expression …

Dysregulated expression and activity of cathepsin S (CTSS), a lysosomal protease and a
member of the cysteine cathepsin protease family, is linked to the pathogenesis of multiple …

Using spatial cell-type-enriched transcriptomics, we compare plaque-induced gene (PIG)
expression in microglia-touching plaques, neighboring plaques, and far from plaques in an …

Cysteine proteases are important targets for the discovery of novel therapeutics for many
human diseases. From parasitic diseases to cancer, cysteine proteases follow a common …

Decline in skeletal muscle cell size (myofiber atrophy) is a key feature of cancer-induced
wasting (cachexia). In particular, atrophy of the diaphragm, the major muscle responsible for …

Introduction Mobility disability is a powerful indicator of poor health in older adults. The
biological and pathophysiological mechanism underlying the development of mobility …

Skeletal muscle is highly sensitive to mutations in genes that participate in membrane
stability and cellular attachment, which often leads to muscular dystrophy. Here we show …

Abstract Aims: Muscle damage in Duchenne muscular dystrophy (DMD) caused by the lack
of dystrophin is strongly linked to inflammation. Heme oxygenase-1 (HO-1; Hmox1) is an anti …

Thrombospondins (Thbs) are a family of five secreted matricellular glycoproteins in
vertebrates that broadly affect cell-matrix interaction. While Thbs4 is known to protect striated …

Exposure to chronic psychological stress (CPS) is an intractable risk factor for inflammatory
and metabolic diseases. Lysosomal cysteinyl cathepsins play an important role in human …