Senescent cell accumulation has been implicated in the pathogenesis of aging-associated
diseases, including cancer. The mechanism that prevents the accumulation of senescent …

Early diagnosis is essential for completely eradicating skin cancer and maximizing patients'
clinical benefits. Emerging optical imaging modalities such as reflectance confocal …

Melanocytes exhibit a complex and intriguing relationship with the skin immune response,
leading to several clinical conditions. In some disorders, inappropriate melanocyte …

Giant congenital melanocytic nevi are NRAS-driven proliferations that may cover up to 80%
of the body surface. Their most dangerous consequence is progression to melanoma. This …

Immunosuppression commonly disrupts the homeostasis of mutated normal skin, leading to
widespread skin dysplasia and field cancerization. However, the immune system's role in …

Epigenetic alterations have emerged as essential contributors in the pathogenesis of
various human diseases, including cutaneous melanoma (CM). Unlike genetic changes …

The mechanism and function of the expression of Schwann characteristics by nevus cells in
the mature zone of the dermis are unknown. Early growth response 3 (EGR3) induces …