Human placenta and trophoblast development: key molecular mechanisms and model systems

M Knöfler, S Haider, L Saleh, J Pollheimer… - Cellular and Molecular …, 2019 - Springer
Abnormal placentation is considered as an underlying cause of various pregnancy
complications such as miscarriage, preeclampsia and intrauterine growth restriction, the …

Placental development: lessons from mouse mutants

J Rossant, JC Cross - Nature Reviews Genetics, 2001 - nature.com
The placenta is the first organ to form during mammalian embryogenesis. Problems in its
formation and function underlie many aspects of early pregnancy loss and pregnancy …

Comparative developmental anatomy of the murine and human definitive placentae

P Georgiades, AC Ferguson-Smith, GJ Burton - Placenta, 2002 - Elsevier
The placenta of eutherian mammals is a remarkable biological structure. It is composed of
both zygote-derived and maternal cells, and mediates the complex interactions between the …

Hemochorial placentation: development, function, and adaptations

MJ Soares, KM Varberg, K Iqbal - Biology of reproduction, 2018 - academic.oup.com
Placentation is a reproductive adaptation that permits fetal growth and development within
the protected confines of the female reproductive tract. Through this important role, the …

Genomic imprinting: implications for human disease

JG Falls, DJ Pulford, AA Wylie, RL Jirtle - The American journal of …, 1999 - Elsevier
Genomic imprinting refers to an epigenetic marking of genes that results in monoallelic
expression. This parent-of-origin dependent phenomenon is a notable exception to the laws …

Physiological functions of imprinted genes

B Tycko, IM Morison - Journal of cellular physiology, 2002 - Wiley Online Library
Genomic imprinting in gametogenesis marks a subset of mammalian genes for parent‐of‐
origin‐dependent monoallelic expression in the offspring. Embryological and classical …

Gene density and transcription influence the localization of chromatin outside of chromosome territories detectable by FISH

NL Mahy, PE Perry, WA Bickmore - The Journal of cell biology, 2002 - rupress.org
Genes can be transcribed from within chromosome territories; however, the major
histocompatibilty complex locus has been reported extending away from chromosome …

[PDF][PDF] Genes, development and evolution of the placenta

JC Cross, D Baczyk, N Dobric, M Hemberger… - Placenta, 2003 - researchgate.net
Comparing the placenta from one species to another can be a challenging task. On one
hand, the gross anatomy of the placenta is at least superficially rather different among …

[HTML][HTML] Hypoxia directs human extravillous trophoblast differentiation in a hypoxia-inducible factor–dependent manner

AK Wakeland, F Soncin, M Moretto-Zita… - The American journal of …, 2017 - Elsevier
Villous cytotrophoblasts are epithelial stem cells of the early human placenta, able to
differentiate either into syncytiotrophoblasts in floating chorionic villi or extravillous …

Genetic insights into trophoblast differentiation and placental morphogenesis

JC Cross - Seminars in cell & developmental biology, 2000 - Elsevier
The placenta is comprised of an inner vascular network covered by an outer epithelium,
called trophoblast, all designed to promote the delivery of nutrients to the fetus. Several …