Mass spectrometry based biomarkers for early detection of HCC using a glycoproteomic approach

Y Mechref, W Peng, S Gautam, P Ahmadi, Y Lin… - Advances in cancer …, 2023 - Elsevier
Hepatocellular carcinoma (HCC) is the fourth most common cause of cancer-related
mortality worldwide and 80%–90% of HCC develops in patients that have underlying …

Conformational dynamics of α‐1 acid glycoprotein (AGP) in cancer: A comparative study of glycosylated and unglycosylated AGP

B Dixit, W Vranken, A Ghysels - Proteins: Structure, Function …, 2024 - Wiley Online Library
Abstract α‐1 acid glycoprotein (AGP) is one of the most abundant plasma proteins. It fulfills
two important functions: immunomodulation, and binding to various drugs and receptors …

Biochemical diagnosis of congenital disorders of glycosylation.

A Raynor, W Haouari, E Lebredonchel… - Advances in Clinical …, 2024 - europepmc.org
Congenital disorders of glycosylation (CDG) are one of the fastest growing groups of inborn
errors of metabolism, comprising over 160 described diseases to this day. CDG are …

New avenues for human blood plasma biomarker discovery via improved in-depth analysis of the low-abundant N-glycoproteome

FJ Zuniga-Banuelos, M Hoffmann, U Reichl, E Rapp - bioRxiv, 2023 - biorxiv.org
To understand implications of protein glycosylation for clinical diagnostic and
biopharmaceuticals, innovative glycoproteomic technologies are required. Recently …