Acute myeloid leukemia (AML) is a complex, aggressive myeloid neoplasm characterized by
frequent somatic mutations that influence different functional categories' genes, resulting in …

Myelodysplastic syndrome (MDS) is a group of heterogeneous clonal hematopoietic stem
cell disorders characterized by cytopenia, ineffective hematopoiesis, and progression to …

Diagnostics of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) have
recently been experiencing extensive modifications regarding the incorporation of next …

The treatment of cancer has traditionally been based on the identification of a single
molecule and/or enzymatic function (target) responsible for a particular phenotype, and …

Autophagy, a highly conserved cellular protein degradation process, has been involved in
acute myeloid leukemia (AML). The present study aims to establish a novel, autophagy …

Polyphyllin I (PPI), a bioactive component extracted from Paris polyphylla, was reported to
have potent anticancer activities in previous studies. However, there were few reports on the …

Clonal cytopenia of undetermined significance (CCUS) is characterized by persistent
cytopenias with genetic aberrations, which do not meet the diagnostic criteria for …

A fundamental question in evolutionary biology is how heritable variability originates. In
Darwinian evolution a central focus was placed on the thinking that random variations are …

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling
pathway has been known to be involved in cell growth, cellular differentiation processes …

Owing to the introduction of next-generation sequencing (NGS) new challenges for
diagnostic algorithms and the interpretation of the results for therapeutic decision making in …