Harmfulness of particulate matter in disease progression

JK Choi, IS Choi, KK Cho, SH Lee - Journal of Life Science, 2020 - koreascience.kr
As society develops rapidly, environmental pollution is becoming a greater risk factor
threatening human health. One of the major causes of air pollution that affects human health …

Animal models of silicosis: fishing for new therapeutic targets and treatments

A Martínez-López, S Candel… - European Respiratory …, 2023 - Eur Respiratory Soc
Silicosis as an occupational lung disease has been present in our lives for centuries.
Research studies have already developed and implemented many animal models to study …

Quercetin Enhances Ligand-induced Apoptosis in Senescent Idiopathic Pulmonary Fibrosis Fibroblasts and Reduces Lung Fibrosis In Vivo

MS Hohmann, DM Habiel, AL Coelho… - American journal of …, 2019 - atsjournals.org
Although cellular senescence may be a protective mechanism in modulating proliferative
capacity, fibroblast senescence is now recognized as a key pathogenic mechanism in …

Loss of IGFBP2 mediates alveolar type 2 cell senescence and promotes lung fibrosis

C Chin, R Ravichandran, K Sanborn, T Fleming… - Cell Reports …, 2023 - cell.com
Accumulation of senescent cells contributes to age-related diseases including idiopathic
pulmonary fibrosis (IPF). Insulin-like growth factor binding proteins (IGFBPs) regulate many …

SARS-CoV-2 N Protein Induces Acute Lung Injury in Mice via NF-ĸB Activation

J Xia, W Tang, J Wang, D Lai, Q Xu, R Huang… - Frontiers in …, 2021 - frontiersin.org
Background Infection of SARS-CoV-2 may cause acute respiratory syndrome. It has been
reported that SARS-CoV-2 nucleocapsid protein (N-protein) presents early in body fluids …

[HTML][HTML] HIF1A-dependent induction of alveolar epithelial PFKFB3 dampens acute lung injury

CU Vohwinkel, N Burns, E Coit, X Yuan, EK Vladar… - JCI insight, 2022 - ncbi.nlm.nih.gov
Acute lung injury (ALI) is a severe form of lung inflammation causing acute respiratory
distress syndrome in patients. ALI pathogenesis is closely linked to uncontrolled alveolar …

Molecular elucidation of biological response to mesoporous silica nanoparticles in vitro and in vivo

CC Chou, W Chen, Y Hung… - ACS applied materials & …, 2017 - ACS Publications
Biomedical applications of mesoporous silica nanoparticles (MSNs) require efficient cellular
uptake and low toxicity. The purpose of this study is to investigate the cellular uptake and …

Lipopolysaccharide induces acute lung injury and alveolar haemorrhage in association with the cytokine storm, coagulopathy and AT1R/JAK/STAT augmentation in a …

B Al‐Ani, AM ShamsEldeen, SS Kamar… - Clinical and …, 2022 - Wiley Online Library
Progress in the study of Covid‐19 disease in rodents has been hampered by the lack of
angiotensin‐converting enzyme 2 (ACE2; virus entry route to the target cell) affinities for the …

Overview of vertebrate animal models of fungal infection

TM Hohl - Journal of immunological methods, 2014 - Elsevier
Fungi represent emerging infectious threats to human populations worldwide. Mice and
other laboratory animals have proved invaluable in modeling clinical syndromes associated …

Cold-inducible RNA-binding protein induces neutrophil extracellular traps in the lungs during sepsis

Y Ode, M Aziz, H Jin, A Arif, JG Nicastro, P Wang - Scientific Reports, 2019 - nature.com
Extracellular cold-inducible RNA-binding protein (CIRP) exaggerates inflammation and
tissue injury in sepsis. Neutrophil extracellular traps (NETs) are released by activated …