Background. Older persons have an increased risk of developing respiratory impairment
because the aging lung is likely to have experienced exposures to environmental toxins as …

From the first measurements of the distribution of pulmonary blood flow using radioactive
tracers by West and colleagues (J Clin Invest 40: 1–12, 1961) allowing gravitational …

In vivo radioactive tracer and microsphere studies have differing conclusions as to the
magnitude of the gravitational effect on the distribution of pulmonary blood flow. We …

The gravitational gradient of intrapleural pressure is suggested to be less in prone posture
than supine. Thus the gravitational distribution of ventilation is expected to be more uniform …

Rationale: In the CLAIM study, dual bronchodilation with indacaterol/glycopyrronium
(IND/GLY) significantly reduced hyperinflation, which translated into improved cardiac …

Background Free‐breathing phase‐resolved functional lung (PREFUL)‐MRI may be useful
for treatment monitoring in chronic obstructive pulmonary disease (COPD) patients with …

Specific ventilation (SV) is the ratio of fresh gas entering a lung region divided by its end-
expiratory volume. To quantify the vertical (gravitationally dependent) gradient of SV in eight …

Multiple thoracic imaging modalities have been developed to link structure to function in the
diagnosis and monitoring of lung disease. Volumetric computed tomography (CT) renders …

Prone posture increases cardiac output and improves pulmonary gas exchange. We
hypothesized that, in the supine posture, greater compression of dependent lung limits …

Aging is associated with a progressive deterioration in the structure and function of the
pulmonary circulation. Remodeling of the pulmonary vasculature occurs from maturity to …