The transcription factor Nuclear factor erythroid 2-related factor 2 (Nrf2) has been mainly
investigated as a regulator of redox homeostasis. However, research over the past years …

The CANTOS (Canakinumab Anti-inflammatory Thrombosis Outcome Study) and colchicine
trials suggest an important role of inflammasomes and their major product IL-1β (interleukin …

Although the immunomodulatory and cytoprotective properties of itaconate have been
studied extensively, it is not known whether its naturally occurring isomers mesaconate and …

Severe forms of malaria are associated with systemic inflammation and host metabolism
disorders; however, the interplay between these outcomes is poorly understood. Using a …

Itaconate is a newly discovered endogenous metabolite promoting an anti-inflammatory
program during innate immune response, but the precise mechanisms underlying its effect …

With advances in immunometabolic studies, more and more evidence has shown that
metabolic changes profoundly affect the immune function of macrophages. The tricarboxylic …

Macrophages undergo extensive metabolic reprogramming during classical pro-
inflammatory polarization (M1-like). The accumulation of itaconate has been recognized as …

In recent years branched short-chain dicarboxylates (BSCD) such as itaconic acid gained
increasing interest in both medicine and biotechnology. Their use as building blocks for …

The metabolite itaconate (ITA) and its derivatives, both chemically synthesized and
endogenous, have emerged as immunoregulators, with roles in limiting inflammation but …

Highlights•Itaconate modulates metabolic pathways relevant to tumor growth.•Itaconate
influences immune cell function and TME.•Itaconate inhibits TET methylcytosine …