Medicinal properties of cannabinoids, terpenes, and flavonoids in cannabis, and benefits in migraine, headache, and pain: an update on current evidence and …

EP Baron - Headache: The Journal of Head and Face Pain, 2018 - Wiley Online Library
Background Comprehensive literature reviews of historical perspectives and evidence
supporting cannabis/cannabinoids in the treatment of pain, including migraine and …

Neurobiological interactions between stress and the endocannabinoid system

M Morena, S Patel, JS Bains, MN Hill - Neuropsychopharmacology, 2016 - nature.com
Stress affects a constellation of physiological systems in the body and evokes a rapid shift in
many neurobehavioral processes. A growing body of work indicates that the …

[HTML][HTML] The endocannabinoid system in guarding against fear, anxiety and stress

B Lutz, G Marsicano, R Maldonado… - Nature Reviews …, 2015 - nature.com
The endocannabinoid (eCB) system has emerged as a central integrator linking the
perception of external and internal stimuli to distinct neurophysiological and behavioural …

[HTML][HTML] Synapse-specific astrocyte gating of amygdala-related behavior

M Martin-Fernandez, S Jamison, LM Robin… - Nature …, 2017 - nature.com
The amygdala plays key roles in fear and anxiety. Studies of the amygdala have largely
focused on neuronal function and connectivity. Astrocytes functionally interact with neurons …

Patterns of medicinal cannabis use, strain analysis, and substitution effect among patients with migraine, headache, arthritis, and chronic pain in a medicinal cannabis …

EP Baron, P Lucas, J Eades, O Hogue - The journal of headache and pain, 2018 - Springer
Background Medicinal cannabis registries typically report pain as the most common reason
for use. It would be clinically useful to identify patterns of cannabis treatment in migraine and …

Integrating endocannabinoid signaling and cannabinoids into the biology and treatment of posttraumatic stress disorder

MN Hill, P Campolongo, R Yehuda… - …, 2018 - nature.com
Exposure to stress is an undeniable, but in most cases surmountable, part of life. However,
in certain individuals, exposure to severe or cumulative stressors can lead to an array of …

Distribution of the endocannabinoid system in the central nervous system

SSJ Hu, K Mackie - Endocannabinoids, 2015 - Springer
The endocannabinoid system consists of endogenous cannabinoids (endocannabinoids),
the enzymes that synthesize and degrade endocannabinoids, and the receptors that …

EIN2 mediates direct regulation of histone acetylation in the ethylene response

F Zhang, L Wang, B Qi, B Zhao, EE Ko… - Proceedings of the …, 2017 - National Acad Sciences
Ethylene gas is essential for developmental processes and stress responses in plants.
Although the membrane-bound protein EIN2 is critical for ethylene signaling, the mechanism …

[HTML][HTML] Genetic disruption of 2-arachidonoylglycerol synthesis reveals a key role for endocannabinoid signaling in anxiety modulation

BC Shonesy, RJ Bluett, TS Ramikie, R Báldi… - Cell reports, 2014 - cell.com
Endocannabinoid (eCB) signaling has been heavily implicated in the modulation of anxiety
and depressive behaviors and emotional learning. However, the role of the most-abundant …

Don't worry, be happy: endocannabinoids and cannabis at the intersection of stress and reward

ND Volkow, AJ Hampson… - Annual Review of …, 2017 - annualreviews.org
Cannabis enables and enhances the subjective sense of well-being by stimulating the
endocannabinoid system (ECS), which plays a key role in modulating the response to …