What drives the flow of signals controlling the outcome of post-transcriptional regulation of
gene expression? This regulatory layer, presiding to processes ranging from splicing to …

RNA-binding proteins (RBPs) are key regulators in post-transcriptional control of gene
expression. Mutations that alter their activity or abundance have been implicated in …

The combination of high-throughput sequencing and in vivo crosslinking approaches leads
to the progressive uncovering of the complex interdependence between cellular …

Here we introduce cat RAPID omics, a server for large-scale calculations of protein–RNA
interactions. Our web server allows (i) predictions at proteomic and transcriptomic level;(ii) …

The long non-coding RNA Xist induces heterochromatinization of the X chromosome by
recruiting repressive protein complexes to chromatin. Here we gather evidence, from the …

Aggregation of RNA-binding proteins (RBPs) is a pathological hallmark of
neurodegenerative disorders like amyotrophic lateral sclerosis (ALS) and frontotemporal …

The human transcriptome contains thousands of long non-coding RNAs (lncRNAs).
Characterizing their function is a current challenge. An emerging concept is that lncRNAs …

The tumor suppressor protein p53 loses its function in more than 50% of human malignant
tumors. Recent studies have suggested that mutant p53 can form aggregates that are …

Amyotrophic lateral sclerosis and frontotemporal lobar degeneration are incurable motor
neuron diseases associated with muscle weakness, paralysis and respiratory failure …

Autogenous interactions between mRNAs and the proteins they encode are implicated in
cellular feedback-loop regulation, but their extent and mechanistic foundation are unclear. It …